Conformational analysis of the IQSEC2 protein by statistical thermodynamics

Mutations in the IQSEC2 gene result in severe intellectual disability, epilepsy and autism. The primary function of IQSEC2 is to serve as a guanine exchange factor (GEF) controlling the activation of ARF6 which in turn mediates membrane trafficking and synaptic connections between neurons. As IQSEC2...

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Bibliographic Details

Published in:	Current research in structural biology Vol. 8; p. 100158
Main Authors:	Shokhen, Michael, Albeck, Amnon, Borisov, Veronika, Israel, Yonat, Levy, Nina S., Levy, Andrew P.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-01-2024 Elsevier
Subjects:	Accelerated molecular dynamics Ensemble method of Gibbs Protein dimerization Protein folding Statistical thermodynamics Protein dimerization Statistical thermodynamics Accelerated molecular dynamics Ensemble method of Gibbs Protein folding
Online Access:	Get full text
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