Proteomic characterization and biological activities of the mucus produced by the zoanthid Palythoa caribaeorum (Duchassaing & Michelotti, 1860)

Proteomic characterization and biological activities of the mucus produced by the zoanthid Palythoa caribaeorum (Duchassaing & Michelotti, 1860)

Mucus, produced by Palythoa caribaeorum has been popularly reported due to healing, anti-inflammatory, and analgesic effects. However, biochemical and pharmacological properties of this mucus remains unexplored. Therefore, the present study aimed to study its proteome profile by 2DE electrophoresis...

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Published in:Anais da Academia Brasileira de Ciências Vol. 95; no. 4; p. e20200325
Main Authors: Silva, Marllyn M, Campos, Thiers A, Cavalcanti, Isabella M F, Oliveira, Idjane S, Pérez, Carlos Daniel, Silva, Roberto Afonso DA, Wanderley, Marcela S O, Santos, Noemia P S
Format: Journal Article
Language:English
Published: Brazil Academia Brasileira de Ciências 01-01-2023
Subjects:
Animals
Anthozoa - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial
cytotoxicity
Microbial Sensitivity Tests
Mucus - microbiology
MULTIDISCIPLINARY SCIENCES
Palythoa
Proteins
proteomic
Proteomics
Palythoa
proteomic
Antibacterial
cytotoxicity
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Abstract Mucus, produced by Palythoa caribaeorum has been popularly reported due to healing, anti-inflammatory, and analgesic effects. However, biochemical and pharmacological properties of this mucus remains unexplored. Therefore, the present study aimed to study its proteome profile by 2DE electrophoresis and MALDI-TOF. Furthermore, it was evaluated the cytotoxic, antibacterial, and antioxidant activities of the mucus and from its protein extract (PE). Proteomics study identified14 proteins including proteins involved in the process of tissue regeneration and death of tumor cells. The PE exhibited cell viability below 50% in the MCF-7 and S-180 strains. It showed IC50 of 6.9 μg/mL for the J774 lineage, and also, favored the cellular growth of fibroblasts. Furthermore, PE revealed activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Staphylococcus epidermidis (MIC of 250 μg/mL). These findings revealed the mucus produced by Palythoa caribaeorum with biological activities, offering alternative therapies for the treatment of cancer and as a potential antibacterial agent.
AbstractList Abstract Mucus, produced by Palythoa caribaeorum has been popularly reported due to healing, anti-inflammatory, and analgesic effects. However, biochemical and pharmacological properties of this mucus remains unexplored. Therefore, the present study aimed to study its proteome profile by 2DE electrophoresis and MALDI-TOF. Furthermore, it was evaluated the cytotoxic, antibacterial, and antioxidant activities of the mucus and from its protein extract (PE). Proteomics study identified14 proteins including proteins involved in the process of tissue regeneration and death of tumor cells. The PE exhibited cell viability below 50% in the MCF-7 and S-180 strains. It showed IC50 of 6.9 μg/mL for the J774 lineage, and also, favored the cellular growth of fibroblasts. Furthermore, PE revealed activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Staphylococcus epidermidis (MIC of 250 μg/mL). These findings revealed the mucus produced by Palythoa caribaeorum with biological activities, offering alternative therapies for the treatment of cancer and as a potential antibacterial agent.
Mucus, produced by Palythoa caribaeorum has been popularly reported due to healing, anti-inflammatory, and analgesic effects. However, biochemical and pharmacological properties of this mucus remains unexplored. Therefore, the present study aimed to study its proteome profile by 2DE electrophoresis and MALDI-TOF. Furthermore, it was evaluated the cytotoxic, antibacterial, and antioxidant activities of the mucus and from its protein extract (PE). Proteomics study identified14 proteins including proteins involved in the process of tissue regeneration and death of tumor cells. The PE exhibited cell viability below 50% in the MCF-7 and S-180 strains. It showed IC50 of 6.9 μg/mL for the J774 lineage, and also, favored the cellular growth of fibroblasts. Furthermore, PE revealed activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Staphylococcus epidermidis (MIC of 250 μg/mL). These findings revealed the mucus produced by Palythoa caribaeorum with biological activities, offering alternative therapies for the treatment of cancer and as a potential antibacterial agent.
Author Pérez, Carlos Daniel
Silva, Marllyn M
Campos, Thiers A
Cavalcanti, Isabella M F
Santos, Noemia P S
Oliveira, Idjane S
Silva, Roberto Afonso DA
Wanderley, Marcela S O
AuthorAffiliation Universidade de Pernambuco
Centro Tecnológico do Nordeste
Universidade Federal de Pernambuco
AuthorAffiliation_xml – name: Centro Tecnológico do Nordeste
– name: Universidade Federal de Pernambuco
– name: Universidade de Pernambuco
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  givenname: Marllyn M
  orcidid: 0000-0002-1768-9831
  surname: Silva
  fullname: Silva, Marllyn M
  organization: Universidade Federal de Pernambuco, Centro Acadêmico de Vitória, Núcleo de Biologia, Rua Alto do Reservatório, s/n, Bela Vista, 55608-680 Vitória de Santo Antão, PE, Brazil
– sequence: 2
  givenname: Thiers A
  orcidid: 0000-0003-4452-2217
  surname: Campos
  fullname: Campos, Thiers A
  organization: Centro Tecnológico do Nordeste, Av. Prof. Luís Freire, 1, Cidade Universitária, 50740-545 Recife, PE, Brazil
– sequence: 3
  givenname: Isabella M F
  orcidid: 0000-0002-7889-3502
  surname: Cavalcanti
  fullname: Cavalcanti, Isabella M F
  organization: Universidade Federal de Pernambuco, Instituto Keizo-Asami (iLIKA), Av. Prof. Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, Brazil
– sequence: 4
  givenname: Idjane S
  orcidid: 0000-0002-8854-5018
  surname: Oliveira
  fullname: Oliveira, Idjane S
  organization: Universidade Federal de Pernambuco, Centro Acadêmico de Vitória, Núcleo de Biologia, Rua Alto do Reservatório, s/n, Bela Vista, 55608-680 Vitória de Santo Antão, PE, Brazil
– sequence: 5
  givenname: Carlos Daniel
  orcidid: 0000-0002-0866-1183
  surname: Pérez
  fullname: Pérez, Carlos Daniel
  organization: Universidade Federal de Pernambuco, Centro Acadêmico de Vitória, Núcleo de Biologia, Rua Alto do Reservatório, s/n, Bela Vista, 55608-680 Vitória de Santo Antão, PE, Brazil
– sequence: 6
  givenname: Roberto Afonso DA
  orcidid: 0000-0002-7958-6053
  surname: Silva
  fullname: Silva, Roberto Afonso DA
  organization: Universidade Federal de Pernambuco, Instituto Keizo-Asami (iLIKA), Av. Prof. Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, Brazil
– sequence: 7
  givenname: Marcela S O
  orcidid: 0000-0002-4236-5820
  surname: Wanderley
  fullname: Wanderley, Marcela S O
  organization: Universidade de Pernambuco, Campus Santo Amaro, Instituto de Ciências Biológicas, Arnóbio Marques, 310, Santo Amaro, 50100-130 Recife, PE, Brazil
– sequence: 8
  givenname: Noemia P S
  orcidid: 0000-0002-0960-6135
  surname: Santos
  fullname: Santos, Noemia P S
  organization: Universidade Federal de Pernambuco, Centro Acadêmico de Vitória, Núcleo de Biologia, Rua Alto do Reservatório, s/n, Bela Vista, 55608-680 Vitória de Santo Antão, PE, Brazil
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Issue 4
Keywords Palythoa
proteomic
Antibacterial
cytotoxicity
Language English
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Snippet Mucus, produced by Palythoa caribaeorum has been popularly reported due to healing, anti-inflammatory, and analgesic effects. However, biochemical and...
Abstract Mucus, produced by Palythoa caribaeorum has been popularly reported due to healing, anti-inflammatory, and analgesic effects. However, biochemical and...
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SubjectTerms Animals
Anthozoa - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial
cytotoxicity
Microbial Sensitivity Tests
Mucus - microbiology
MULTIDISCIPLINARY SCIENCES
Palythoa
Proteins
proteomic
Proteomics
Title Proteomic characterization and biological activities of the mucus produced by the zoanthid Palythoa caribaeorum (Duchassaing & Michelotti, 1860)
URI https://www.ncbi.nlm.nih.gov/pubmed/38055606
https://search.proquest.com/docview/2899372807
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