Therapeutic potential of tLyp-1-EV-shCTCF in inhibiting liver cancer stem cell self-renewal and immune escape via SALL3 modulation in hepatocellular carcinoma

•Sparse SALL3 expression in HCC foretells undesirable patient outcomes.•Boosting SALL3 impedes DNMT3A-facilitated mtDNA methylation and glycolytic adaptations.•CTCF favors H3K27me3 embellishments, constraining SALL3 output.•tLyp-1-EV-shCTCF's bolstering of SALL3 offsets metabolic drifts and LCS...

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Bibliographic Details

Published in:	Translational oncology Vol. 49; p. 102048
Main Authors:	Zhu, Heng, Xie, Zhihui
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-11-2024 Neoplasia Press Elsevier
Subjects:	DNMT3A Extracellular vesicles Hepatocellular carcinoma Liver cancer stem cells Original Research SALL3 Self-renewal tLyp-1 peptide Self-renewal tLyp-1 peptide SALL3 DNMT3A Extracellular vesicles Hepatocellular carcinoma Liver cancer stem cells
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