Pre-operative DTI and probabilisitic tractography in four patients with deep brain stimulation for chronic pain

• Published in: Journal of clinical neuroscience Vol. 15; no. 7; pp. 801 - 805
• Main Authors: Owen, S.L.F, Heath, J, Kringelbach, M, Green, A.L, Pereira, E.A.C, Jenkinson, N, Jegan, T, Stein, J.F, Aziz, T.Z
• Format: Journal Article
• Language: English
• Published: Scotland Elsevier Ltd 01-07-2008
• Subjects: Brain Mapping - methods; Chronic Disease; Deep brain stimulation; Deep Brain Stimulation - instrumentation; Deep Brain Stimulation - methods; Diffusion Magnetic Resonance Imaging - methods; Diffusion tensor imaging; Electrodes, Implanted; Humans; Models, Statistical; Monitoring, Physiologic - instrumentation; Monitoring, Physiologic - methods; Neural Pathways - anatomy & histology; Neural Pathways - physiology; Neural Pathways - surgery; Neurology; Pain; Pain, Intractable - etiology; Pain, Intractable - physiopathology; Pain, Intractable - therapy; Periaqueductal Gray - anatomy & histology; Periaqueductal Gray - physiology; Periaqueductal Gray - surgery; Periaqueductal grey; Periventricular grey; Postoperative Complications - prevention & control; Preoperative Care - instrumentation; Preoperative Care - methods; Probabilistic tractography; Stereotaxic Techniques - instrumentation; Periventricular grey; Pain; Probabilistic tractography; Deep brain stimulation; Periaqueductal grey; Diffusion tensor imaging
• ISSN: 0967-5868; 1532-2653
• DOI: 10.1016/j.jocn.2007.06.010

Abstract This study aimed to examine, using diffusion tensor imaging (DTI), differences in electrode placement in four patients undergoing deep brain stimulation for chronic neuropathic pain of varying aetiology. A pre-operative DTI was obtained for each patient, who was then implanted with deep brain stimulation electrodes in the periventricular/periaqueductal grey area with good pain relief. Using seeds from the postoperative MRI scan, probabilistic tractography was performed from the pre-operative DTI.