Case Report: Deutetrabenazine as an Adjunctive Treatment for Stuttering
Childhood-Onset Fluency Disorder (Stuttering) is a neurodevelopmental disorder in which disturbances occur in the normal fluency and time patterning of speech. While the dopamine system has been well-described in its neurophysiology, there currently is no FDA-approved treatment for stuttering. Secon...
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| Published in: | Frontiers in psychiatry Vol. 12 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
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25-10-2021
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| Abstract | Childhood-Onset Fluency Disorder (Stuttering) is a neurodevelopmental disorder in which disturbances occur in the normal fluency and time patterning of speech. While the dopamine system has been well-described in its neurophysiology, there currently is no FDA-approved treatment for stuttering. Second-generation antipsychotics, which have been effective in the treatment of schizophrenia and bipolar disorder, act as dopamine D-2 receptor antagonists at the postsynaptic neuron and have been shown to reduce the symptoms of stuttering. However, the D-2 receptor antagonist and partial agonist agents carry the potential for metabolic side effects and can potentially lead to movement disorders. Deutetrabenazine, a VMAT-2 inhibitor indicated to treat hyperkinetic movement disorders, is a potential candidate in the treatment of stuttering, based on its mechanism of action in decreasing dopamine activity while not carrying the risk of metabolic adverse events. |
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| AbstractList | Childhood-Onset Fluency Disorder (Stuttering) is a neurodevelopmental disorder in which disturbances occur in the normal fluency and time patterning of speech. While the dopamine system has been well-described in its neurophysiology, there currently is no FDA-approved treatment for stuttering. Second-generation antipsychotics, which have been effective in the treatment of schizophrenia and bipolar disorder, act as dopamine D-2 receptor antagonists at the postsynaptic neuron and have been shown to reduce the symptoms of stuttering. However, the D-2 receptor antagonist and partial agonist agents carry the potential for metabolic side effects and can potentially lead to movement disorders. Deutetrabenazine, a VMAT-2 inhibitor indicated to treat hyperkinetic movement disorders, is a potential candidate in the treatment of stuttering, based on its mechanism of action in decreasing dopamine activity while not carrying the risk of metabolic adverse events. |
| Author | Ha, Catherine A. Maguire, Gerald A. |
| AuthorAffiliation | 1 School of Medicine, University of California, Riverside , Riverside, CA , United States 2 Department of Psychiatry and Neuroscience, University of California, Riverside , Riverside, CA , United States |
| AuthorAffiliation_xml | – name: 1 School of Medicine, University of California, Riverside , Riverside, CA , United States – name: 2 Department of Psychiatry and Neuroscience, University of California, Riverside , Riverside, CA , United States |
| Author_xml | – sequence: 1 givenname: Catherine A. surname: Ha fullname: Ha, Catherine A. – sequence: 2 givenname: Gerald A. surname: Maguire fullname: Maguire, Gerald A. |
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| Cites_doi | 10.1080/10401230490452834 10.1097/MED.0b013e32833de61c 10.1016/S1353-8020(99)00015-2 10.1016/j.jcomdis.2004.03.001 10.3389/fnins.2020.00158 10.1176/appi.books.9780890425596 10.5334/tohm.165 |
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| Copyright | Copyright © 2021 Ha and Maguire. 2021 Ha and Maguire |
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| Notes | Edited by: Mirko Manchia, University of Cagliari, Italy Reviewed by: Giorgio Pigato, University Hospital of Padua, Italy; Pasquale Paribello, University of Cagliari, Italy This article was submitted to Psychopharmacology, a section of the journal Frontiers in Psychiatry |
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| References | Waln (B4) 2013 Maguire (B7) 2004; 16 Hoang (B3) 2016; 28 Chouinard (B10) 2004; 65 Pramyothin (B12) 2010; 17 (B2) 2013 Alm (B5) 2004; 37 Yairi (B6) 2004 Shaygannejad (B9) 2013; 4 Maguire (B8) 2020; 14 B1 Ortí-Pareja (B11) 1999; 5 |
| References_xml | – volume: 28 start-page: 64 year: 2016 ident: B3 article-title: Case report of aripiprazole in the treatment of adolescent stuttering publication-title: Ann Clin Psychiatry. contributor: fullname: Hoang – volume: 16 start-page: 63 year: 2004 ident: B7 article-title: Olanzapine in the treatment of developmental stuttering: a double-blind, placebo-controlled trial publication-title: Ann Clin Psychiatry. doi: 10.1080/10401230490452834 contributor: fullname: Maguire – volume: 17 start-page: 460 year: 2010 ident: B12 article-title: Metabolic syndrome with the atypical antipsychotics publication-title: Curr Opin Endocrinol Diabet Obes. doi: 10.1097/MED.0b013e32833de61c contributor: fullname: Pramyothin – volume-title: Early Childhood Stuttering year: 2004 ident: B6 contributor: fullname: Yairi – volume: 65 start-page: 9 year: 2004 ident: B10 article-title: New nomenclature for drug-induced movement disorders including tardive dyskinesia publication-title: J Clin Psychiatry. contributor: fullname: Chouinard – volume: 5 start-page: 59 year: 1999 ident: B11 article-title: Drug-induced tardive syndromes publication-title: Parkinsonism Relat Disord. doi: 10.1016/S1353-8020(99)00015-2 contributor: fullname: Ortí-Pareja – volume: 37 start-page: 325 year: 2004 ident: B5 article-title: Stuttering and the basal ganglia circuits: a critical review of possible relations publication-title: J Commun Disord. doi: 10.1016/j.jcomdis.2004.03.001 contributor: fullname: Alm – volume: 4 start-page: S270 year: 2013 ident: B9 article-title: Olanzapine versus haloperidol: which can control stuttering better? publication-title: Int J Prev Med. contributor: fullname: Shaygannejad – volume: 14 start-page: 158 year: 2020 ident: B8 article-title: The pharmacologic treatment of stuttering and its neuropharmacologic basis publication-title: Front Neurosci. doi: 10.3389/fnins.2020.00158 contributor: fullname: Maguire – ident: B1 – year: 2013 ident: B2 publication-title: Diagnostic and Statistical Manual of Mental Disorders. doi: 10.1176/appi.books.9780890425596 – start-page: 3 year: 2013 ident: B4 article-title: An update on tardive dyskinesia: from phenomenology to treatment publication-title: Tremor Other Hyperkinet Mov. doi: 10.5334/tohm.165 contributor: fullname: Waln |
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| Title | Case Report: Deutetrabenazine as an Adjunctive Treatment for Stuttering |
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