Transcription factor activation and mitogenic synergism in airway smooth muscle cells

Simultaneous treatment of human airway smooth muscle (HASM) cells with lysophosphatidic acid (LPA) and epidermal growth factor (EGF) leads to strikingly synergistic stimulation of mitogenesis. The purpose of this study was to explore potential sites for signal integration mediating synergism, focusi...

Full description

Saved in:

Bibliographic Details
Published in:	The European respiratory journal Vol. 21; no. 5; pp. 759 - 769
Main Authors:	Ediger, T.L, Schulte, N.A, Murphy, T.J, Toews, M.L
Format:	Journal Article
Language:	English
Published:	Leeds Eur Respiratory Soc 01-05-2003 Maney
Subjects:	Acute-Phase Proteins - metabolism Air breathing Biological and medical sciences Botulinum Toxins - pharmacology Cell Transformation, Neoplastic - drug effects Cell Transformation, Neoplastic - metabolism Cells, Cultured Epidermal Growth Factor - pharmacology Fundamental and applied biological sciences. Psychology Humans Lysophospholipids - pharmacology MAP Kinase Signaling System - physiology Mitogens - metabolism Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Trachea Transcription Factor AP-1 - metabolism Transcription Factors - metabolism Vertebrates: respiratory system Human Extracellular signal-regulated protein kinase Activator protein-1 asthma growth factors nuclear factor-κB proliferation Rho Enzyme Respiratory system Synergism Biological activity Myocyte Respiratory tract Epidermal growth factor Lysophosphatidic acid Mitogen Transcription factor NFκB Transcription factor AP1
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!