Data on environmentally relevant level of aflatoxin B1-induced human dendritic cells' functional alteration

• Published in: Data in brief Vol. 18; pp. 1576 - 1580
• Main Authors: Mehrzad, Jalil, Bahari, Abbas, Bassami, Mohammad Reza, Mahmoudi, Mahmoud, Dehghani, Hesam
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-06-2018; Elsevier
• Subjects: AFB1; AFB1-detoxifying genes; Apoptosis; Chemistry; Dendritic cells; Flow cytometry; Functional genes; Immunnoderegulation; Phagocytosis; RT-qPCR; Flow cytometry; Dendritic cells; Functional genes; AFB1; Immunnoderegulation; RT-qPCR; Phagocytosis; Apoptosis; AFB1-detoxifying genes
• ISSN: 2352-3409; 2352-3409
• DOI: 10.1016/j.dib.2018.04.104

We assessed the effects of naturally occurring levels of AFB1 on the expression of key immune molecules and function of human monocyte-derived dendritic cells (MDDCs) by cell culture, RT-qPCR, and flow cytometry. Data here revealed that an environmentally relevant level of AFB1 led to remarkably weakened key functional capacity of DCs, up-regulation of key transcripts and DCs apoptosis, down-regulation of key phagocytic element, CD64, and creation of pseudolicensing direction of DCs. Flow cytometry data confirmed a damage towards DCs, i.e., increased apoptosis. The detailed data and their mechanistic effects and the outcome are available in this research article (Mehrzad et al., 2018) [1]. The impaired phagocytosis capacity with triggered pseudolicensing direction of MDDCs caused by AFB1 and dysregulation of the key functional genes could provide a mechanistic explanation for the observed in vivo immunotoxicity associated with this mycotoxin.