Analgesic properties of the aqueous and ethanol extracts of the leaves of Kalanchoe crenata (Crassulaceae)

• Published in: Phytotherapy research Vol. 18; no. 5; pp. 385 - 388
• Main Authors: Nguelefack, T.B, Fotio, A.L, Watcho, P, Wansi, S.L, Dimo, T, Kamanyi, A
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01-05-2004; Wiley
• Subjects: Acetic Acid; analgesic activity; analgesic effect; Analgesics - administration & dosage; Analgesics - pharmacology; Analgesics - therapeutic use; Animals; Biological and medical sciences; Dose-Response Relationship, Drug; Female; Formaldehyde; formalin; General pharmacology; heat; Hot Temperature; Kalanchoe; Kalanchoe crenata; Male; Medical sciences; medicinal plants; Mice; Pain - chemically induced; Pain - prevention & control; Pain Measurement - drug effects; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; plant extracts; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Pressure; Rats; Rats, Wistar; traditional medicine; heat; Prostaglandin-endoperoxide synthase; Rat; Crassulaceae; Indometacin; Opiates; Extract; Narcotic analgesic; Prevention; Paracetamol; Pain; formalin; Dicotyledones; Angiospermae; Indoleacetic acid derivatives; analgesic activity; Kalanchoe; Ethanol; Enzyme; Antimigrainous agent; Rodentia; Enzyme inhibitor; Kalanchoe crenata; Antitussive agent; Plant leaf; pressure; Non steroidal antiinflammatory agent; Vertebrata; Mammalia; Mouse; Animal; Antipyretic; Spermatophyta; Oxidoreductases; Acetic acid
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.1444

The aqueous and ethanol extracts of the dry leaves of Kalanchoe crenata (300 and 600 mg/kg) were evaluated for their analgesic properties on the pain induced by acetic acid, formalin and heat in mice and by pressure on rats. The ethanol extract of K. crenata at a dose of 600 mg/kg produced an inhibition of 61.13% on pain induced by acetic acid and 50.13% for that induced by formalin. An inhibition of 67.18% was observed on pain induced by heat 45 min after the administration of the extract. The aqueous extract administered at a dose of 600 mg/kg produced a maximum effect of 25% on pain induced by pressure. These activities were similar to those produced by a paracetamol–codeine association, while indomethacin exhibited a protective effect only against the writhing test. Our results suggest that the leaves of K. crenata could be a source of analgesic compounds. Copyright © 2004 John Wiley & Sons, Ltd.