Gain of Function Mutations in Membrane Region M2C2 of KtrB Open a Gate Controlling K+ Transport by the KtrAB System from Vibrio alginolyticus

KtrB, the K+-translocating subunit of the Na+-dependent bacterial K+ uptake system KtrAB, consists of four M1PM2 domains, in which M1 and M2 are transmembrane helices and P indicates a p-loop that folds back from the external medium into the cell membrane. The transmembrane stretch M2C is, with its...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 285; no. 14; pp. 10318 - 10327
Main Authors:	Hänelt, Inga, Löchte, Sara, Sundermann, Lea, Elbers, Katharina, Vor der Brüggen, Marc, Bakker, Evert P.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 02-04-2010 American Society for Biochemistry and Molecular Biology
Subjects:	Amino Acid Sequence Bacteria Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Biological Transport Cation Transport Proteins - chemistry Cation Transport Proteins - genetics Cation Transport Proteins - metabolism Cell Membrane - metabolism Enzyme Kinetics Escherichia coli - genetics Escherichia coli - metabolism Membrane Biology Membrane Proteins Molecular Sequence Data Mutation - genetics Potassium - metabolism Potassium Transport Sequence Homology, Amino Acid Site-directed Mutagenesis Sodium - metabolism Vibrio alginolyticus Vibrio alginolyticus - genetics Vibrio alginolyticus - metabolism Membrane Proteins Site-directed Mutagenesis Bacteria Enzyme Kinetics Potassium Transport
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