Thrombomodulin modulates cell migration in human melanoma cell lines

Malignant melanoma cells are known to have altered expressions of growth factors as compared with normal melanocytes. Thrombomodulin (TM) is a thrombin receptor on endothelial cells that converts thrombin from a procoagulant to an anticoagulant enzyme. TM expression is downregulated in tumor cells,...

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Bibliographic Details
Published in:	Melanoma research Vol. 24; no. 1; pp. 11 - 19
Main Authors:	de Oliveira, Andreia da Silva, Yang, Likiu, Echevarria-Lima, Juliana, Monteiro, Robson Q, Rezaie, Alireza R
Format:	Journal Article
Language:	English
Published:	England 01-02-2014
Subjects:	Adenomatous Polyposis Coli Protein - pharmacology Antigens, CD - biosynthesis Cell Line, Tumor Cell Movement - physiology Disease Progression Down-Regulation Endothelial Protein C Receptor Humans Interleukin-8 - biosynthesis Melanocytes - metabolism Melanocytes - pathology Melanoma - genetics Melanoma - metabolism Melanoma - pathology Neoplasm Invasiveness Receptors, Cell Surface - biosynthesis RNA, Messenger - biosynthesis RNA, Messenger - genetics Thrombin - pharmacology Thrombomodulin - genetics Thrombomodulin - metabolism Thromboplastin - biosynthesis Transfection
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