Photophysics of diphenyl-pyrazole compounds in solutions and α-synuclein aggregates

Recently diphenyl-pyrazole (DPP) compounds and especially anle138b were found to reduce the aggregation of α-synuclein or Tau protein in vitro as well as in a mouse model of neurodegenerative diseases [1,2]. Direct interaction of the DPPs with the fibrillar structure was identified by fluorescence s...

Full description

Saved in:

Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1862; no. 4; pp. 800 - 807
Main Authors:	Reiner, Anne M., Schmidt, Felix, Ryazanov, Sergey, Leonov, Andrei, Weckbecker, Daniel, Deeg, Andreas A., Griesinger, Christian, Giese, Armin, Zinth, Wolfgang
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-04-2018
Subjects:	alpha-Synuclein - chemistry alpha-Synuclein - metabolism anle138b Benzodioxoles - chemistry Benzodioxoles - metabolism Binding Sites Diphenyl-pyrazole Fluorescence Parkinson's disease Protein Aggregates Protein aggregation Protein Binding Pyrazoles - chemistry Pyrazoles - metabolism Spectrometry, Fluorescence α-synuclein Fluorescence Diphenyl-pyrazole Protein aggregation anle138b Parkinson's disease α-synuclein
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!