Plasma membranes as heat stress sensors: From lipid-controlled molecular switches to therapeutic applications

The classic heat shock (stress) response (HSR) was originally attributed to protein denaturation. However, heat shock protein (Hsp) induction occurs in many circumstances where no protein denaturation is observed. Recently considerable evidence has been accumulated to the favor of the “Membrane Sens...

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Published in:	Biochimica et biophysica acta Vol. 1838; no. 6; pp. 1594 - 1618
Main Authors:	Török, Zsolt, Crul, Tim, Maresca, Bruno, Schütz, Gerhard J., Viana, Felix, Dindia, Laura, Piotto, Stefano, Brameshuber, Mario, Balogh, Gábor, Péter, Mária, Porta, Amalia, Trapani, Alfonso, Gombos, Imre, Glatz, Attila, Gungor, Burcin, Peksel, Begüm, Vigh, László, Csoboz, Bálint, Horváth, Ibolya, Vijayan, Mathilakath M., Hooper, Phillip L., Harwood, John L.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-06-2014
Subjects:	Animals Cell Membrane - metabolism Cell-to-cell heterogeneity Heat shock response Heat-Shock Proteins - metabolism Heat-Shock Response - physiology Humans Lipid raft Lipidomics Membrane lipid therapy Membrane Lipids - metabolism Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - therapy Stress hormone TRP channel APAP Cell-to-cell heterogeneity GPI SGT SPC Membrane lipid therapy CHO Cdase MPS POPE MBCD TRP PI3K GSK3 MD POPC Ld mTOR DMPC CHOL AA Lipid raft Lo aSMase HSP HSR PKA PhA PLA2 Heat shock response PKC Lipidomics MAPK ERK1/2 Stress hormone CRA PIP3 GlcCer LPA DPH LPC PIP2 BA PLC PLD BM PHB NPN EGFR LPS TIRF SFA GFP UFA TRP channel GFR S1P NADA HSF1 SK1 FRET SM YFP MALDI DAG GR IP3 PI4P CaMKII GCS LB TOCCSL ATP HNE
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