Myocardial hypertrophy is prevented by farnesol through oxidative stress and ERK1/2 signaling pathways

Farnesol is a sesquiterpene found in several plants, with multiple pharmacological activities. However, pharmacological actions of farnesol in the treatment of cardiac hypertrophy are not yet reported. This study aimed to investigate the effect and regulatory mechanisms of farnesol against isoproter...

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Bibliographic Details
Published in:	European journal of pharmacology Vol. 887; p. 173583
Main Authors:	Souza, Diego Santos, Barreto, Tatiane de Oliveira, Menezes-Filho, José Evaldo Rodrigues de, Heimfarth, Luana, Rhana, Paula, Rabelo, Thallita Kelly, Santana, Michael Nadson Santos, Durço, Aimée Obolari, Conceição, Michael Ramon de Lima, Quintans-Júnior, Lucindo José, Guimarães, Adriana Gibara, Cruz, Jader Santos, Vasconcelos, Carla Maria Lins de
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15-11-2020
Subjects:	Adrenergic beta-Agonists Animals Antioxidants - metabolism Apoptosis Apoptosis Regulatory Proteins - metabolism Blood Pressure - drug effects Cardiac hypertrophy Cardiomegaly - chemically induced Cardiomegaly - prevention & control Electrocardiography - drug effects Farnesol Farnesol - therapeutic use Isoproterenol Lipid Peroxidation - drug effects Male MAP Kinase Signaling System - drug effects Oxidative Stress - drug effects Rats Rats, Wistar Reactive oxygen species Reactive Oxygen Species - metabolism Ventricular Function, Left - drug effects Cardiac hypertrophy Reactive oxygen species Farnesol Apoptosis
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