Synthesis and characterization of l-carnosine coated iron oxide nanoparticles

• Published in: Journal of alloys and compounds Vol. 509; no. 5; pp. 2555 - 2561
• Main Authors: Durmus, Z., Kavas, H., Baykal, A., Sozeri, H., Alpsoy, L., Çelik, S.Ü., Toprak, M.S.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 03-02-2011; Elsevier
• Subjects: Amino acid; Chemical synthesis methods; Coercive force; Cross-disciplinary physics: materials science; rheology; Crystallites; Exact sciences and technology; Fe 3O 4; Fe3O4; Fittings; Functional materials; Funktionella material; Iron oxides; Magnetic property; Magnetite; Magnetization; Materials science; Methods of nanofabrication; Nanocomposites; Nanoparticles; Nanopowders; Nanoscale materials and structures: fabrication and characterization; Physics; Surface modification; TECHNOLOGY; TEKNIKVETENSKAP; Teknisk materialvetenskap; Transmission electron microscopy; Magnetic property; Surface modification; Fe 3O 4; Amino acid; Nanocomposites; Particle size; Fourier transform spectroscopy; Electrical conductivity; Iron oxide; Line shape; Amino acids; Cytotoxicity; Surface treatments; Superparamagnetism; O; Nanoparticles; Crystallites; Magnetite; Canted spin arrangements; Linkage group; Coercive force; Coated particle; Fourier-transformed infrared spectrometry; Activation energy; Coprecipitation; Saturation magnetization; Magnetic properties; Fe; Crystalline phase; Doses; Composite materials; Transmission electron microscopy; Nanostructured materials
• ISSN: 0925-8388; 1873-4669; 1873-4669
• DOI: 10.1016/j.jallcom.2010.11.088

▶ L-Carnosine coated iron oxide nanoparticles (CCIO NPs) have been prepared via co-precipitation of Fe
3O
4 (magnetite) in the presence of L-carnosine. ▶ FTIR analysis showed that the binding of carnosine onto the surface of iron oxide is through unidentate linkage of carboxyl group. ▶ Magnetization measurements revealed that L-carnosine iron oxide composite has immeasurable coercivity and remanence with absence of hysteritic behavior, which implies superparamagnetic behaviour at room temperature. ▶ The synthesized amino acid-coated magnetic nanoparticles might be applied to cell separation, diagnosis and targeted drug delivery for cancer therapy.
l-Carnosine coated iron oxide nanoparticles (CCIO NPs) have been prepared via co-precipitation of iron oxide in the presence of
l-carnosine. Crystalline phase was identified as magnetite with an average crystallite size of 8
nm as estimated from X-ray line profile fitting. Particle size estimated from TEM by log-normal fitting was ∼11
nm. FTIR analysis showed that the binding of carnosine onto the surface of iron oxide is through unidentate linkage of carboxyl group. CCIO NPs showed superparamagnetic charactersitic at room temperature. The magnetic core size of superparamagnetic CCIO NPs was found slightly smaller than the size obtained from TEM, due to the presence of magnetically dead layer. Magnetization measurements revealed that
l-carnosine iron oxide composite has immeasurable coercivity and remanence with absence of hysteritic behavior, which implies superparamagnetic behavior at room temperature. The low value of saturation magnetization compared to the bulk magnetite has been explained by spin canting. LDH activity tests showed slight cytotoxicity of high dose of CCIO NPs. The
ac conductivity of CCIO NPs was found to be greater than that of carnosine and the effective conduction mechanism was found as correlated barrier hopping (CBH).
dc activation energy of the product at around room temperature was measured as 0.312
eV which was in good agreement with the earlier reports.