Serine protease inhibitors containing a Kunitz domain: their role in modulation of host inflammatory responses and parasite survival
Proteins containing a Kunitz domain have the typical serine protease inhibition function ranging from sea anemone to man. Protease inhibitors play major roles in infection, inflammation disorders and cancer. This review discusses the role of serine proteases containing a Kunitz domain in immunomodul...
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| Published in: | Microbes and infection Vol. 20; no. 9-10; pp. 606 - 609 |
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| Abstract | Proteins containing a Kunitz domain have the typical serine protease inhibition function ranging from sea anemone to man. Protease inhibitors play major roles in infection, inflammation disorders and cancer. This review discusses the role of serine proteases containing a Kunitz domain in immunomodulation induced by helminth parasites. Helminth parasites are associated with protection from inflammatory conditions. Therefore, interest has raised whether worm parasites or their products hold potential as drugs for treatment of immunological disorders. Finally, we also propose the use of recombinant SmKI-1 from Schistosoma mansoni as a potential therapeutic molecule to treat inflammatory diseases. |
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| AbstractList | Proteins containing a Kunitz domain have the typical serine protease inhibition function ranging from sea anemone to man. Protease inhibitors play major roles in infection, inflammation disorders and cancer. This review discusses the role of serine proteases containing a Kunitz domain in immunomodulation induced by helminth parasites. Helminth parasites are associated with protection from inflammatory conditions. Therefore, interest has raised whether worm parasites or their products hold potential as drugs for treatment of immunological disorders. Finally, we also propose the use of recombinant SmKI-1 from Schistosoma mansoni as a potential therapeutic molecule to treat inflammatory diseases. |
| Author | Mambelli, Fábio S. Morais, Suellen B. Santos, Bruno P.O. Oliveira, Sergio C. de Magalhães, Mariana T.Q. |
| Author_xml | – sequence: 1 givenname: Mariana T.Q. surname: de Magalhães fullname: de Magalhães, Mariana T.Q. organization: Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil – sequence: 2 givenname: Fábio S. surname: Mambelli fullname: Mambelli, Fábio S. organization: Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil – sequence: 3 givenname: Bruno P.O. surname: Santos fullname: Santos, Bruno P.O. organization: Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil – sequence: 4 givenname: Suellen B. surname: Morais fullname: Morais, Suellen B. organization: Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil – sequence: 5 givenname: Sergio C. orcidid: 0000-0003-4062-5577 surname: Oliveira fullname: Oliveira, Sergio C. email: scozeus@icb.ufmg.br organization: Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29355617$$D View this record in MEDLINE/PubMed |
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| Keywords | Schistosoma mansoni SmKI-1 Kunitz inhibitors Immunomodulation |
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| Title | Serine protease inhibitors containing a Kunitz domain: their role in modulation of host inflammatory responses and parasite survival |
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