Human leukocyte antigen-G 3’ untranslated region polymorphisms are associated with asthma severity

•Asthma presents differential inflammatory responses according to disease severity.•HLA-G inhibits the function of the innate and adaptive immune responses.•A gene region close to HLA-G has been independently associated with asthma.•HLA-G 3’UTR polymorphisms are associated with HLA-G production.•Two...

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Bibliographic Details
Published in:	Molecular immunology Vol. 101; pp. 500 - 506
Main Authors:	Alves, Cinthia C., Arruda, Luísa K.P., Oliveira, Fabíola R., Massaro, Juliana D., Aquino, Beatriz J., Paz, Michelle A., Castelli, Erick C., Mendes-Junior, Celso T., Donadi, Eduardo A.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-09-2018
Subjects:	3' Untranslated Regions - genetics Adolescent Adult Aged Aged, 80 and over Asthma Asthma - genetics Asthma - pathology Child Female Gene Frequency - genetics Genetic Predisposition to Disease Haplotypes - genetics HLA-G HLA-G Antigens - genetics Humans Linkage Disequilibrium - genetics Male MHC Middle Aged Mild asthma Polymorphism, Single Nucleotide - genetics Severe asthma Severity of Illness Index Susceptibility Young Adult MHC Mild asthma Severe asthma Susceptibility HLA-G Asthma
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