The challenge of Propionibacterium acnes and revision shoulder arthroplasty: a review of current diagnostic options

• Published in: Journal of shoulder and elbow surgery Vol. 25; no. 6; pp. 1034 - 1040
• Main Authors: Shields, Margaret V., BS, Abdullah, Leath, BS, Namdari, Surena, MD, MSc
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-06-2016
• Subjects: alpha-Defensins - blood; arthroplasty; Arthroplasty, Replacement, Shoulder - adverse effects; Biomarkers - blood; C-Reactive Protein - metabolism; Erythrocyte Indices; Gram-Positive Bacterial Infections - blood; Gram-Positive Bacterial Infections - diagnosis; Gram-Positive Bacterial Infections - microbiology; Humans; Infection; Orthopedics; P. acnes; periprosthetic joint infection; Propionibacterium acnes; Propionibacterium acnes - isolation & purification; Prosthesis-Related Infections - blood; Prosthesis-Related Infections - diagnosis; Prosthesis-Related Infections - microbiology; Reoperation - adverse effects; Sensitivity and Specificity; shoulder; Infection; Review Article; P. acnes; arthroplasty; periprosthetic joint infection; Propionibacterium acnes; shoulder
• ISSN: 1058-2746; 1532-6500
• DOI: 10.1016/j.jse.2016.01.009

Background Propionibacterium acnes is the most common cause of infection after shoulder arthroplasty. Whereas there are several methods that can aid in the diagnosis of P. acnes infection, there is not a single "gold standard" because of the difficulties inherent in identifying this bacterium. We present an evidence-based discussion of the demographic, clinical, and radiographic predictors of P. acnes infection and review the current options for diagnosis. Methods This review was written after a comprehensive analysis of the current literature related to shoulder periprosthetic joint infection and P. acnes identification. Results and Conclusions Of the techniques reviewed, α-defensin had the highest sensitivity in detecting P. acnes infection (63%). C-reactive protein level and erythrocyte sedimentation rate were often normal in cases of infection. Whereas P. acnes can be challenging to successfully diagnose, there are several options that are considered preferable because of their higher sensitivities and specificities. The current gold standard is intraoperative culture, but major advances in molecular techniques may provide future improvements in diagnostic accuracy.