Interindividual differences in posterior fossa morphometry affect cerebellar tDCS-induced electric field strength

• Published in: Clinical neurophysiology Vol. 153; pp. 152 - 165
• Main Authors: Maas, Roderick P.P.W.M., Faber, Jennifer, van de Warrenburg, Bart P.C., Schutter, Dennis J.L.G.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-09-2023
• Subjects: Cerebellar tDCS; Electric fields; Electrode position; Focality; Modelling study; Simulation; Modelling study; Cerebellar tDCS; Simulation; Electric fields; Electrode position; Focality
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2023.06.019

•Skin-cerebellum distance is the dominant factor determining cerebellar tDCS-induced electric field strength in healthy adults.•Interindividual differences in posterior fossa morphometry add unique explanatory variance to skin-cerebellum distance.•When targeting the midline cerebellum, field strength and focality differ between cephalic and extracephalic electrode montages.
Clinical, behavioural, and neurophysiological effects of cerebellar transcranial direct current stimulation (tDCS) are highly variable and difficult to predict. We aimed to examine associations between cerebellar tDCS-induced electric field strength, morphometric posterior fossa parameters, and skin-cerebellum distance. As a secondary objective, field characteristics were compared between cephalic and extracephalic electrode configurations.
Electric field simulations of midline cerebellar tDCS (7 × 5 cm electrodes, current intensities of 2 mA) were performed on MRI-based head models from 37 healthy adults using buccinator, frontopolar, and lower neck reference electrodes. Average field strengths were determined in eight regions of interest (ROIs) covering the anterior and posterior vermis and cerebellar hemispheres. Besides skin-cerebellum distance, various angles were measured between posterior fossa structures. Multivariable linear regression models were used to identify predictors of field strength in different ROIs.
Skin-cerebellum distance and “pons angle” were independently associated with field strength in the anterior and posterior vermis. “Cerebellar angle” and skin-cerebellum distance affected field strength in anterior and posterior regions of the right cerebellar hemisphere. Field strengths in all examined cerebellar areas were highest in the frontopolar and lowest in the lower neck montage, while the opposite was found for field focality. The lower neck montage induced considerably less spreading toward anterior cerebellar regions compared with the buccinator and frontopolar montages, which resulted in a more evenly distributed field within the cerebellum.
In addition to skin-cerebellum distance, interindividual differences in posterior fossa morphometry, specifically pons and cerebellar angle, explain part of the variability in cerebellar tDCS-induced electric field strength. Furthermore, when targeting the midline cerebellum with tDCS, an extracephalic reference electrode is associated with lower field strengths and higher field focality than cephalic montages.
This study identifies two novel subject-specific anatomical factors that partly determine cerebellar tDCS-induced electric field strength and reveals differences in field characteristics between electrode montages.