Auto-regulation of Slug mediates its activity during epithelial to mesenchymal transition

Slug, a five C2H2 zinc finger (ZF) motif transcription factor mediates cell migration in development, adult tissue repair and regeneration, as well as during tumor metastases through epithelial to mesenchymal transition. At the molecular level, this involves interactions with E-box (CACC/GGTG) conse...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1849; no. 9; pp. 1209 - 1218
Main Authors:	Kumar, Brijesh, Uppuladinne, Mallikarjunachari V.N., Jani, Vinod, Sonavane, Uddhavesh, Joshi, Rajendra R., Bapat, Sharmila A.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-09-2015
Subjects:	Autoregulation Cell Line, Tumor EMT Epithelial-Mesenchymal Transition - physiology Female Gene Expression Regulation - genetics Humans Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Promoter Regions, Genetic Protein Binding Slug Snail Family Transcription Factors Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Transcription, Genetic - genetics SS Autoregulation MMPSBA ZF ChIP Slug EMT PDB TF TSS EMSA MD TGF-β
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