A new strategy of iontophoresis for hyperhidrosis

• Published in: Journal of the American Academy of Dermatology Vol. 22; no. 2 Pt 1; p. 239
• Main Authors: Shen, J L, Lin, G S, Li, W M
• Format: Journal Article
• Language: English
• Published: United States 01-02-1990
• Subjects: Aluminum - therapeutic use; Aluminum Chloride; Aluminum Compounds; Chlorides - therapeutic use; Double-Blind Method; Female; Glycopyrrolate - therapeutic use; Humans; Hyperhidrosis - therapy; Iontophoresis - methods; Male; Seasons; Time Factors
• ISSN: 0190-9622
• DOI: 10.1016/0190-9622(90)70031-C

We used a modified iontophoretic method with an anticholinergic agent and aluminum chloride to treat hyperhidrosis. The strategy behind this combination was to shift gradually from inhibition of sweat gland secretion to blockage of the sweat duct. In a double-blind study in which we compared our method with tap water iontophoresis, the results were comparable. A second study revealed an 87% response rate, with an average remission period of 32 days. Our data indicate that patients who were older at onset, had a family history negative for the disorder, had an early response, or underwent treatment in cool weather had the most favorable results.