Balanced Heterodyne Brillouin Spectroscopy Towards Tissue Characterization

• Published in: IEEE access Vol. 10; pp. 24340 - 24348
• Main Authors: Schunemann, Melanie, Sperlich, Karsten, Barnscheidt, Kai, Schopa, Samuel, Wenzel, Johannes, Kalies, Stefan, Heisterkamp, Alexander, Stolz, Heinrich, Stachs, Oliver, Hage, Boris
• Format: Journal Article
• Language: English
• Published: Piscataway IEEE 2022; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Biomechanics; Brillouin scattering; Frequency measurement; Frequency ranges; Laser beams; Measurement by laser beam; measurement techniques; optical mixing; Photodiodes; Quantum optics; Scattering; Spectroscopy; Spectrum analysis; Tissues
• ISSN: 2169-3536; 2169-3536
• DOI: 10.1109/ACCESS.2022.3154424

We present the first application of balanced heterodyne detection, established in quantum optics, to Brillouin spectroscopy in biological tissues. The balanced detection cancels out a large part of the influence of the laser noise. The center wavelength is 1064nm and the frequency resolution is 30MHz. The frequency resolution and the accessible frequency range are only limited by the measurement time and the laser tuning range (30GHz), respectively. In this way, we were able to measure the Brillouin shift in acetone, water, gummy bears, glass, and even porcine eye lenses.