Fas Ligand Induction in Human NK Cells Is Regulated by Redox Through a Calcineurin-Nuclear Factors of Activated T Cell-Dependent Pathway

Fas ligand (FasL) on cytotoxic lymphocytes is important for mediating apoptosis of activated lymphocytes and other target cells. We have reported that NK cell functions, such as proliferation, cell death, and killing activity, are subject to regulation by cellular redox status. Here, we report that...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 162; no. 4; pp. 1988 - 1993
Main Authors:	Furuke, Keizo, Shiraishi, Mitsuhiro, Mostowski, Howard S, Bloom, Eda T
Format:	Journal Article
Language:	English
Published:	United States Am Assoc Immnol 15-02-1999
Subjects:	Antibodies, Monoclonal - pharmacology Calcineurin - physiology Calcineurin Inhibitors Cells, Cultured Culture Media, Conditioned DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - physiology Enzyme Activation - drug effects Enzyme Activation - immunology Fas Ligand Protein fas Receptor - metabolism Humans Hydrogen Peroxide - pharmacology Interleukin-2 - pharmacology Intracellular Fluid - metabolism Killer Cells, Natural - drug effects Killer Cells, Natural - enzymology Killer Cells, Natural - immunology Ligands Lymphocyte Activation - immunology Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics NFATC Transcription Factors Nuclear Proteins Oxidation-Reduction Peroxides - metabolism Receptors, IgG - immunology RNA, Messenger - antagonists & inhibitors RNA, Messenger - metabolism Sulfhydryl Compounds - metabolism T-Lymphocytes - immunology Time Factors Transcription Factors - antagonists & inhibitors Transcription Factors - physiology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!