Identification of transmembrane helix 1 (TM1) surfaces important for EnvZ dimerisation and signal output

The Escherichia coli sensor kinase EnvZ modulates porin expression in response to various stimuli, including extracellular osmolarity, the presence of procaine and interaction with an accessory protein, MzrA. Two major outer membrane porins, OmpF and OmpC, act as passive diffusion-limited pores that...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1858; no. 8; pp. 1868 - 1875
Main Authors:	Heininger, Annika, Yusuf, Rahmi, Lawrence, Robert J., Draheim, Roger R.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-08-2016
Subjects:	Allosteric Regulation Amino Acid Substitution Bacterial Outer Membrane Proteins - chemistry Bacterial Outer Membrane Proteins - genetics Cysteine - chemistry Dimerization EnvZ signalling Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Multienzyme Complexes - chemistry Multienzyme Complexes - genetics Mutagenesis, Site-Directed Osmolar Concentration Osmosensing Porin regulation Protein Domains Protein Structure, Secondary Recombinant Proteins - chemistry Signal Transduction - physiology Sulfhydryl-reactivity Transmembrane communication YFP Osmosensing CFP EDTA SDS-PAGE EnvZ signalling Sulfhydryl-reactivity Transmembrane communication Porin regulation SHK NEM TM2 IPTG TM1 MDR HAMP ATP OM
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