The effects of chemical or surgical deafferentation on [ 3H]-acetylcholine release from rat spinal cord

Cholinergic modulation of nociceptive transmission through both nicotinic and muscarinic receptors in the spinal cord represents an important mechanism in pain signaling. However, what neuronal elements release acetylcholine and how release might change in response to deafferentation are unclear. Th...

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Bibliographic Details
Published in:	Neuroscience Vol. 135; no. 4; pp. 1269 - 1276
Main Authors:	Dussor, G.O., Jones, D.J., Hulsebosch, C.E., Edell, T.A., Flores, C.M.
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 2005 Elsevier
Subjects:	Acetylcholine - pharmacology Acetylcholine - secretion Afferent Pathways - injuries Afferent Pathways - metabolism Afferent Pathways - surgery Animals Biological and medical sciences capsaicin Capsaicin - pharmacology choline choline acetyltransferase Cholinergic Agents - pharmacology Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Hemicholinium 3 - pharmacology Ligation Male neuropathic Organ Culture Techniques pain Pain - metabolism Pain - physiopathology Rats Rats, Sprague-Dawley Rhizotomy Spinal Cord - drug effects Spinal Cord - metabolism Spinal Nerves - drug effects Spinal Nerves - injuries Spinal Nerves - surgery Vertebrates: nervous system and sense organs neuropathic BrACh HC-3 choline pain choline acetyltransferase ACh capsaicin ChAT DRG DRX [ 3H]-ACh Acyltransferases Spinal cord Rat Enzyme Capsaicin Transferases Rodentia Central nervous system Choline O-acetyltransferase Vertebrata Mammalia Pain Animal Surgery Neurotransmitter Acetylcholine Deafferentation Release
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