RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells

RET tyrosine kinase is necessary for enteric nervous system development. Loss-of-function RET mutations cause Hirschsprung disease (HSCR), in which infants are born with aganglionic bowel. Despite surgical correction, patients with HSCR often experience chronic defecatory dysfunction and enterocolit...

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Bibliographic Details
Published in:	Gastroenterology (New York, N.Y. 1943) Vol. 166; no. 3; pp. 437 - 449
Main Authors:	Shepherd, Amy, Feinstein, Laurence, Sabel, Svetlana, Rastelli, Daniella, Mezhibovsky, Esther, Matthews, Lynley, Muppirala, Anoohya, Robinson, Ariel, Sharma, Karina R., ElSeht, Abrahim, Zeve, Daniel, Breault, David T., Gershon, Michael D., Rao, Meenakshi
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-03-2024
Subjects:	Animals Enteric Nervous System Enteroendocrine Cells Glucagon-Like Peptide 1 Hirschsprung Disease - genetics Humans Infant Inhibitory Motor Neurons Intestine, Small Male Mice Neurotrophic Factor Peptide YY Proto-Oncogene Proteins c-ret - genetics Serotonin Sex Differences CHGA EEC GI Sex Differences GITT GLP-1 FPO NPY2R ENS CFP PYY CALB1 ANOVA HSCR NOS1 Neurotrophic Factor VIP 5-HT Inhibitory Motor Neurons
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