Skin metabolism phase I and phase II enzymes in native and reconstructed human skin: a short review

•Understanding human skin models encourages their use in xenobiotic metabolism testing.•Skin models indicate relevant expression and activity of phase II metabolizing enzymes.•Skin shows properties of chemical detoxification and elimination in vitro and ex vivo.•More physiologically relevant models...

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Bibliographic Details

Published in:	Drug discovery today Vol. 24; no. 9; pp. 1899 - 1910
Main Authors:	Kazem, Siamaque, Linssen, Emma Charlotte, Gibbs, Susan
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-09-2019
Online Access:	Get full text
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