TRAIL induces apoptosis but not necroptosis in colorectal and pancreatic cancer cells preferentially via the TRAIL-R2/DR5 receptor

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine that can trigger apoptosis in many types of human cancer cells via engagement of its two pro-apoptotic receptors TRAIL-R1 (DR4) and TRAIL-R2 (DR5). TRAIL can also activate several other signaling pathways such as activatio...

Full description

Saved in:

Bibliographic Details
Published in:	Biochimica et biophysica acta. Molecular cell research Vol. 1865; no. 3; pp. 522 - 531
Main Authors:	Nahacka, Zuzana, Svadlenka, Jan, Peterka, Martin, Ksandrova, Marie, Benesova, Simona, Neuzil, Jiri, Andera, Ladislav
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-03-2018
Subjects:	Apoptosis Apoptosis - genetics Cancer Caspase 8 - genetics Cell Proliferation - genetics Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Gene Expression Regulation, Neoplastic HT29 Cells Humans Necroptosis Necrosis - genetics Necrosis - pathology NF-kappa B - genetics Pancreas - metabolism Pancreas - pathology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Receptor-specific signaling Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics RNA, Small Interfering Signal Transduction - genetics TNF-Related Apoptosis-Inducing Ligand - genetics TRAIL Receptor-specific signaling TRAIL Necroptosis Apoptosis Cancer
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!