A signaling-induced switch in dicer localization and function

In this issue of Developmental Cell, Drake and colleagues (2014) report that Ras signaling results in Dicer phosphorylation, which induces its nuclear localization and modulates its function. This regulatory strategy, conserved in mammals, allows dynamic control of microRNA function required for Cae...

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Bibliographic Details
Published in:	Developmental cell Vol. 31; no. 5; pp. 523 - 524
Main Authors:	Hu, Fuqu, Lai, Eric C, Okamura, Katsutomo
Format:	Journal Article
Language:	English
Published:	United States 08-12-2014
Subjects:	Animals Caenorhabditis elegans - enzymology MAP Kinase Signaling System - physiology Oocytes - metabolism Ribonuclease III - metabolism RNA, Double-Stranded - metabolism
Online Access:	Get full text
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Summary:	In this issue of Developmental Cell, Drake and colleagues (2014) report that Ras signaling results in Dicer phosphorylation, which induces its nuclear localization and modulates its function. This regulatory strategy, conserved in mammals, allows dynamic control of microRNA function required for Caenorhabditis elegans germline development and oogenesis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Commentary-3 content type line 23
ISSN:	1534-5807 1878-1551
DOI:	10.1016/j.devcel.2014.11.032