SuHx rat model: partly reversible pulmonary hypertension and progressive intima obstruction

The SU5416 combined with hypoxia (SuHx) rat model features angio-obliterative pulmonary hypertension resembling human pulmonary arterial hypertension. Despite increasing use of this model, a comprehensive haemodynamic characterisation in conscious rats has not been reported. We used telemetry to cha...

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Bibliographic Details
Published in:	The European respiratory journal Vol. 44; no. 1; pp. 160 - 168
Main Authors:	DE RAAF, Michiel Alexander, SCHALIJ, Ingrid, GOMEZ-ARROYO, Jose, ROL, Nina, HAPPE, Chris, DE MAN, Frances S, VONK-NOORDEGRAAF, Anton, WESTERHOF, Nico, VOELKEL, Norbert F, BOGAARD, Harm Jan
Format:	Journal Article
Language:	English
Published:	Leeds Maney 01-07-2014
Subjects:	Angiogenesis Inhibitors - chemistry Animals Biological and medical sciences Circadian Rhythm Disease Models, Animal Disease Progression Echocardiography Heart Ventricles - pathology Hemodynamics Humans Hypertension, Pulmonary - physiopathology Hypertrophy, Right Ventricular - physiopathology Hypoxia - physiopathology Indoles - chemistry Lung - physiopathology Male Medical sciences Pneumology Pulmonary Artery - pathology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Pyrroles - chemistry Rats Rats, Sprague-Dawley Systole Telemetry Tunica Intima - pathology Vascular Remodeling Progressive Animal model Vertebrata Mammalia Rat Respiratory disease Rodentia Intima Cardiovascular disease Obstruction Pulmonary hypertension
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