Anomanolide C suppresses tumor progression and metastasis by ubiquitinating GPX4-driven autophagy-dependent ferroptosis in triple negative breast cancer

Anomanolide C (AC), a natural withanolide isolated from , has been reported to have exhibits remarkable anti-tumour activities in several types of human cancers, particularly triple-negative breast cancer (TNBC). However, its intricate mechanisms still remain need to be clarified. Here, we evaluated...

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Bibliographic Details
Published in:	International journal of biological sciences Vol. 19; no. 8; pp. 2531 - 2550
Main Authors:	Chen, Yan-Mei, Xu, Wei, Liu, Yang, Zhang, Jia-Hui, Yang, Yuan-Yuan, Wang, Zhi-Wen, Sun, De-Juan, Li, Hua, Liu, Bo, Chen, Li-Xia
Format:	Journal Article
Language:	English
Published:	Australia Ivyspring International Publisher Pty Ltd 01-01-2023 Ivyspring International Publisher
Subjects:	Antibodies Anticancer properties Apoptosis Autophagy Breast cancer Cancer therapies Cell culture Cell Line, Tumor Cell Proliferation Chemotherapy Drug development Ferroptosis Humans Metastases Metastasis Oxidative stress Proteins Research Paper Triple Negative Breast Neoplasms - metabolism Tumors Ubiquitination United States > US China Ferroptosis Ubiquitination GPX4 Anomanolide C Autophagy Triple negative breast cancer
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