E96V Mutation in the Kdelr3 Gene Is Associated with Type 2 Diabetes Susceptibility in Obese NZO Mice

Type 2 diabetes (T2D) represents a multifactorial metabolic disease with a strong genetic predisposition. Despite elaborate efforts in identifying the genetic variants determining individual susceptibility towards T2D, the majority of genetic factors driving disease development remain poorly underst...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 24; no. 1; p. 845
Main Authors:	Altenhofen, Delsi, Khuong, Jenny Minh-An, Kuhn, Tanja, Lebek, Sandra, Görigk, Sarah, Kaiser, Katharina, Binsch, Christian, Griess, Kerstin, Knebel, Birgit, Belgardt, Bengt-Frederik, Cames, Sandra, Eickelschulte, Samaneh, Stermann, Torben, Rasche, Axel, Herwig, Ralf, Weiss, Jürgen, Vogel, Heike, Schürmann, Annette, Chadt, Alexandra, Al-Hasani, Hadi
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI 03-01-2023 MDPI AG
Subjects:	Animals Diabetes Mellitus, Type 2 - genetics endoplasmic reticulum stress Genetic Predisposition to Disease Insulin - metabolism insulin secretion Insulin-Secreting Cells - metabolism Mice Mice, Inbred C3H Mice, Obese Obesity - genetics pancreatic islet function positional cloning Receptors, Peptide - genetics type 2 diabetes susceptibility positional cloning insulin secretion type 2 diabetes susceptibility endoplasmic reticulum stress pancreatic islet function
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