Glucocorticoid Receptor Agonist Dexamethasone Attenuates Renal Ischemia/Reperfusion Injury by Up-regulating eNOS/iNOS

The aim of this study was to determine the effect of dexamethasone（DEX） on renal ischemia/reperfusion injury（IRI）. C57BL/6 mice were randomly divided into Sham group, IRI group and DEX group. The mice in IRI and DEX groups subjected to renal ischemia for 60 min, were treated with saline or DEX（4 mg/...

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Published in:	Journal of Huazhong University of Science and Technology. Medical sciences Vol. 34; no. 4; pp. 516 - 520
Main Author:	张炯李俊华王艻韩敏肖芳兰小勤李月强徐钢姚颖
Format:	Journal Article
Language:	English
Published:	Heidelberg Huazhong University of Science and Technology 01-08-2014 Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Department of Nephrology, Subsidiary of the Sichuan Academy of Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology, Chengdu 610072, China%Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China%Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Subjects:	Animals Dexamethasone - pharmacology eNOS Gene Expression Regulation, Enzymologic - drug effects Glucocorticoids - pharmacology iNOS Male Medicine Medicine & Public Health Mice Nitric Oxide Synthase Type II - biosynthesis Nitric Oxide Synthase Type III - biosynthesis Receptors, Glucocorticoid - agonists Reperfusion Injury - enzymology Reperfusion Injury - pathology Up-Regulation - drug effects 再灌注损伤受体激动剂地塞米松糖皮质激素受体细胞外信号调节激酶缺血肾功能 dexamethasone ischemia/reperfusion injury nitric oxide synthase
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