Diffusion-Weighted Imaging in Fetuses with Unilateral Cortical Malformations and Callosal Agenesis

• Published in: American journal of neuroradiology : AJNR Vol. 31; no. 6; pp. 1100 - 1102
• Main Authors: GLENN, O. A, QUIROZ, E. M, BERMAN, J. I, STUDHOLME, C, XU, D
• Format: Journal Article
• Language: English
• Published: Oak Brook, IL American Society of Neuroradiology 01-06-2010
• Subjects: Acrocallosal Syndrome - pathology; Adult; Biological and medical sciences; Cerebral Cortex - abnormalities; Cerebral Ventricles - pathology; Diffusion Magnetic Resonance Imaging; Electrocardiography. Vectocardiography; Electrodiagnosis. Electric activity recording; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Malformations of Cortical Development - pathology; Medical sciences; Nerve Fibers, Myelinated - pathology; Nervous system; Pediatrics; Pregnancy; Prenatal Diagnosis; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Young Adult; Agenesis; Nervous system diseases; Radiodiagnosis; Malformation; Nuclear magnetic resonance imaging; Corpus callosum
• ISSN: 0195-6108; 1936-959X
• DOI: 10.3174/ajnr.A1863

DWI was performed in fetuses with callosal agenesis and unilateral cortical malformations. ADC values were retrospectively measured in the developing white matter underlying the cortical malformation and compared with the corresponding contralateral white matter. In all 3 patients, ADC values were lower under the areas of cortical malformation compared with the normal contralateral side. Our findings suggest that there are structural differences in the developing white matter underlying areas of cortical malformation.