Incidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 Brazilian patients with multiple sclerosis

• Published in: Multiple sclerosis Vol. 27; no. 10; pp. 1615 - 1619
• Main Authors: Ferreira, Lis Campos, Sousa, Nise Alessandra de Carvalho, Ferreira, Maria Lucia Brito, Dias-Carneiro, Rafael Paternò Castello, Mendes, Maria Fernanda, Piccolo, Ana Claudia, Thomaz, Rodrigo Barbosa, Vasconcelos, Claudia Cristina Ferreira, Alves-Leon, Soniza Vieira, Santos, Gutemberg Augusto Cruz dos, Pereira, Valéria Coelho Santa Rita, de Oliveira, Enedina Maria Lobato, Pereira, Samira Luisa Apóstolos, Boaventura, Mateus, Disserol, Caio César Diniz, Neto, Herval Ribeiro Soares, Martins, Gabriela Joca, ďAlmeida, José Arthur, Pitombeira, Milena S., Mendes, Lucas Silvestre, Dourado, Mario Emilio Teixeira, de Oliveira, Bianca Etelvina Santos, Guerra, Davi Veloso, Machado, Maria Íris de Morais, Moreira, Alvaro Jose Porto, Fukuda, Thiago, Cabeça, Hideraldo Luís Souza, Rocha, Luciano Chaves, de Vecino, Maria Cecilia Aragon, Silva, Camila Batista Oliveira, Amorim, Leizian de Souza, de Castro, Andréa Anacleto Ferrari, Neto, Antonio Pereira Gomes, Da Rocha, Fernando Coronetti G, Gomes, Sidney, Ruocco, Heloisa Helena, Fragoso, Yara Dadalti, Gonçalves, Marcus vinicius Magno, Pimentel, Maria Lucia Vellutini, Machado (In memorian), Suzana Nunes, Arambula, Omar Gurrola, Grzesiuk, Anderson Kuntz, Kaimen-Maciel, Damacio R, Diniz, Denise Sisterolli, Comini-Frota, Elizabeth R, do Olival, Guilherme Sciascia, Dias, Ronaldo Maciel, Melges, Luiz D, da Gama, Paulo Diniz, Ribeiro, Marlise de Castro, Morales, Rogério de Rizo, de Andrade, Ana Carolina Amaral, Siqueira, Heloise Helena, Parolin, Monica Koncke Fiuza, Sato, Henry Koity, Figueiredo, José Alexandre, Calia, Leandro Cortoni, Scolari, Letícia, Peixoto, Carlos Alberto Magirius, Vieira, Vera Lúcia Ferreira, Menon, Renata Leite, de Sousa, Marlos Aureliano Dias, Sobreira, Silvana, Ribeiro, Taysa A Gonsalves Jubé, Costa, Vanessa Maia, Stella, Carla Renata Aparecida Vieira, Borges, Fernando Elias, Junior, Adaucto Wanderley da Nóbrega, Callegaro, Dagoberto, Donadi, Eduardo Antonio, Adoni, Tarso, Catão, Rafael de Castro, Fortaleza, Carlos Magno Castelo Branco, Miot, Helio Amant, Pugliesi, Edmur, Guimarães, Raul Borges, von Glehn, Felipe, Brum, Doralina G.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-09-2021; Sage Publications Ltd
• Subjects: Clinical outcomes; Coronaviruses; COVID-19; Multiple sclerosis; Pandemics; Patients; Severe acute respiratory syndrome coronavirus 2; COVID-19; Multiple sclerosis; virus infection SARS-CoV2
• ISSN: 1352-4585; 1477-0970
• DOI: 10.1177/1352458520978354

Background:
Little information is available regarding the incidence and clinical outcome of the SARS-CoV2 infection in patients with multiple sclerosis (pwMS).
Objective:
To determine the incidence, clinical outcome, and impact of COVID-19 on pwMS.
Methods:
This observational study was prospectively performed on a cohort of pwMS (N = 11,560) followed up by 47 out of 51 Brazilian MS referral centers that registered pwMS with COVID-19 at the REDONE platform from 13 March to 4 June 2020.
Results:
The incidence of COVID-19 for pwMS patients was 27.7/10,000 patients and for the general population was 29.2/10,000 inhabitants. A total of 94 (77 women) pwMS patients, aged 40 ± 10.25 years, presenting 9.9 ± 8.6 years of MS disease duration, developed the COVID-19, most of them (87%) exhibited the mild form of the disease. Eighty (96%) patients maintained the use of MS disease-modifying treatment (DMT) during COVID-19 pandemic and 14 patients were not in use of DMTs.
Conclusion:
Incidence of COVID-19 in Brazilian pwMS was not different from those observed for the general Brazilian population. Most pwMS exhibited mild COVID-19, despite the maintenance of the underlying MS treatment.