Enzymatic gating of voltage-activated calcium channels

The model of calcium-channel gating described above, although almost certainly too simple, suggests a direct role for protein kinases and phosphatases in determining the kinetics of calcium channel gating on a subsecond time scale. In addition, it provides a unique perspective for understanding stud...

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Bibliographic Details
Published in:	Annals of the New York Academy of Sciences Vol. 635; p. 26
Main Authors:	Armstrong, D L, Rossier, M F, Shcherbatko, A D, White, R E
Format:	Journal Article
Language:	English
Published:	United States 01-01-1991
Subjects:	Animals Calcium Channels - drug effects Calcium Channels - physiology Dihydropyridines - pharmacology Ion Channel Gating - drug effects Ion Channel Gating - physiology Phosphoprotein Phosphatases - metabolism Phosphorylation Protein Kinases - metabolism
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Summary:	The model of calcium-channel gating described above, although almost certainly too simple, suggests a direct role for protein kinases and phosphatases in determining the kinetics of calcium channel gating on a subsecond time scale. In addition, it provides a unique perspective for understanding studies of calcium channel gating under widely different metabolic and pharmacological conditions. Although many of these effects may be specific to the dihydropyridine-sensitive or L-type calcium channel, they give an indication of the range of possibilities for integrating calcium-channel activity with cellular biochemistry.
ISSN:	0077-8923
DOI:	10.1111/j.1749-6632.1991.tb36478.x