Ganoderma applanatum: a promising mushroom for antitumor and immunomodulating activity

• Published in: Phytotherapy research Vol. 22; no. 5; pp. 614 - 619
• Main Authors: Jeong, Yong-Tae, Yang, Byung-Keun, Jeong, Sang-Chul, Kim, Sang-Min, Song, Chi-Hyun
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01-05-2008; Wiley
• Subjects: Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; antitumor; Biological and medical sciences; Biopolymers - chemistry; Biopolymers - isolation & purification; Biopolymers - pharmacology; Cell Line, Tumor; Dose-Response Relationship, Drug; exo-biopolymer; Ganoderma - chemistry; Ganoderma applanatum; General pharmacology; Immunologic Factors - chemistry; Immunologic Factors - isolation & purification; Immunologic Factors - pharmacology; Killer Cells, Natural - drug effects; Killer Cells, Natural - metabolism; Lysosomes - drug effects; Lysosomes - metabolism; Macrophages - drug effects; Macrophages - metabolism; Medical sciences; Mice; Mice, Inbred BALB C; mushroom; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phosphoric Monoester Hydrolases - metabolism; Phytotherapy; Sarcoma 180 - pathology; Sarcoma 180 - prevention & control; Fungi; Antineoplastic agent; exo-biopolymer; Pharmacognosy; antitumor; Plant origin; Ganoderma applanatum; mushroom; Basidiomycota; Medicinal plant
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.2294

The antitumor effect of exo-biopolymer (EXP) produced by Ganoderma applanatum was investigated using sarcoma-180 bearing mice. EXP, when administered (10-80 mg/kg body weight: BW) intraperitoneally, significantly inhibited the growth of solid tumor and increased the natural killer (NK) cell activity. A dose of 40 mg/kg BW was found to be highly effective, as it reduced the tumor formation by 39.7%, and increased the NK cell activity of splenocytes by 51.6% compared with the control group. The complement activity of EXP was increased in accordance with an increase in concentration. The phosphatase activity of macrophages was increased by 0.7-fold (200 μg/mL) compared with the control group. This EXP contained 58.9% carbohydrate and 17.1% protein. The major sugar of EXP was composed of mannose and glucose, while the protein mainly consisted of serine, glycine and aspartic acid. Copyright © 2008 John Wiley & Sons, Ltd.