Endocrinology and metabolism after premature pubarche in girls
The prevalence of functional ovarian hyperandrogenism, hyperinsulinism and dyslipidaemia is increased in adolescent girls with a history of premature pubarche, defined as the appearance of pubic hair before the age of 8 years. The ovarian hyperandrogenism is characterized by clinical signs of androg...
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| Published in: | Acta Paediatrica Vol. 88; no. s433; pp. 73 - 77 |
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| Language: | English |
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01-12-1999
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| Abstract | The prevalence of functional ovarian hyperandrogenism, hyperinsulinism and dyslipidaemia is increased in adolescent girls with a history of premature pubarche, defined as the appearance of pubic hair before the age of 8 years. The ovarian hyperandrogenism is characterized by clinical signs of androgen excess and an exaggerated ovarian 17‐hydroxyprogesterone response to gonadotrophin‐releasing hormone aganist stimulation. The hyperinsulinism and dyslipidaemia are detectable before and during pubertal development, and they are commonly accompanied by low serum levels of insulin‐like growth factor binding protein‐1 (IGEBP‐1) and sex hormone binding globulin, and by an increased prevalence of anovulation from late adolescence onwards. In girls, premature pubarche, hyperinsulinism, low serum levels of IGFBP‐1 dyslipidaemia, anovulation and hyperandrogenism (or various combinations of these conditions) have been related to reduced fetal growth, indicating that these constellations or sequences may have a prenatal origin. These findings suggest that premature pubarche in girls should no longer be regarded as meaely a normal variant of development, but rather as a childhood marker pointing to an increased risk of a polyendocrine‐metabolic disorder of prenatal origin. |
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| AbstractList | The prevalence of functional ovarian hyperandrogenism, hyperinsulinism and dyslipidaemia is increased in adolescent girls with a history of premature pubarche, defined as the appearance of pubic hair before the age of 8 years. The ovarian hyperandrogenism is characterized by clinical signs of androgen excess and an exaggerated ovarian 17‐hydroxyprogesterone response to gonadotrophin‐releasing hormone aganist stimulation. The hyperinsulinism and dyslipidaemia are detectable before and during pubertal development, and they are commonly accompanied by low serum levels of insulin‐like growth factor binding protein‐1 (IGEBP‐1) and sex hormone binding globulin, and by an increased prevalence of anovulation from late adolescence onwards. In girls, premature pubarche, hyperinsulinism, low serum levels of IGFBP‐1 dyslipidaemia, anovulation and hyperandrogenism (or various combinations of these conditions) have been related to reduced fetal growth, indicating that these constellations or sequences may have a prenatal origin. These findings suggest that premature pubarche in girls should no longer be regarded as meaely a normal variant of development, but rather as a childhood marker pointing to an increased risk of a polyendocrine‐metabolic disorder of prenatal origin. The prevalence of functional ovarian hyperandrogenism, hyperinsulinism and dyslipidaemia is increased in adolescent girls with a history of premature pubarche, defined as the appearance of pubic hair before the age of 8 years. The ovarian hyperandrogenism is characterized by clinical signs of androgen excess and an exaggerated ovarian 17‐hydroxyprogesterone response to gonadotrophin‐releasing hormone aganist stimulation. The hyperinsulinism and dyslipidaemia are detectable before and during pubertal development, and they are commonly accompanied by low serum levels of insulin‐like growth factor binding protein‐1 ( IGEBP‐1 ) and sex hormone binding globulin, and by an increased prevalence of anovulation from late adolescence onwards. In girls, premature pubarche, hyperinsulinism, low serum levels of IGFBP‐1 dyslipidaemia, anovulation and hyperandrogenism (or various combinations of these conditions) have been related to reduced fetal growth, indicating that these constellations or sequences may have a prenatal origin. These findings suggest that premature pubarche in girls should no longer be regarded as meaely a normal variant of development, but rather as a childhood marker pointing to an increased risk of a polyendocrine‐metabolic disorder of prenatal origin. The prevalence of functional ovarian hyperandrogenism, hyperinsulinism and dyslipidaemia is increased in adolescent girls with a history of premature pubarche, defined as the appearance of pubic hair before the age of 8 years. The ovarian hyperandrogenism is characterized by clinical signs of androgen excess and an exaggerated ovarian 17-hydroxyprogesterone response to gonadotrophin-releasing hormone agonist stimulation. The hyperinsulinism and dyslipidaemia are detectable before and during pubertal development, and they are commonly accompanied by low serum levels of insulin-like growth factor binding protein-1 (IGFBP-1) and sex hormone binding globulin, and by an increased prevalence of anovulation from late adolescence onwards. In girls, premature pubarche, hyperinsulinism, low serum levels of IGFBP-1, dyslipidaemia, anovulation and hyperandrogenism (or various combinations of these conditions) have been related to reduced fetal growth, indicating that these constellations or sequences may have a prenatal origin. These findings suggest that premature pubarche in girls should no longer be regarded as merely a normal variant of development, but rather as a childhood marker pointing to an increased risk of a polyendocrine-metabolic disorder of prenatal origin. |
| Author | Lbáñez, L Potau, N Zegher, F De |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10626549$$D View this record in MEDLINE/PubMed |
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| References_xml | – volume: 82 start-page: 4075 year: 1997 end-page: 9 article-title: Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17α activity and serum androgens publication-title: J Clin Endocrinol Metab – volume: 166 start-page: 1191 year: 1992 end-page: 7 article-title: Lipid and lipoprotein abnormalities in hirsute women. I. The association with insulin resistance publication-title: Am J Obstet Gynecol – volume: 81 start-page: 878 year: 1996 end-page: 80 article-title: Evidence that idiopathic functional adrenal hyperandrogenism is caussed by dysregulation of adrenal steroidogenesis and that hyperinsulinemia may; be involved (editorial) publication-title: J Clin Endocrinol Metab – volume: 41 start-page: 1057 year: 1998 end-page: 63 article-title: Hyperinsulinaemia, dyslipaemia and cardiovascular risk in girls with a history of premature pubarche publication-title: Diabetologia – volume: 21 start-page: 558 year: 1998 end-page: 66 article-title: Premature pubarche, ovarian hyperinsulinism, hyperandrogenism and the polycystic ovary syndrome: from a complex constellation ato a simple sequence of prenatal onset publication-title: J Endocrinol Invest – volume: 64 start-page: 1113 year: 1995 end-page: 9 article-title: Growth hormone, insulin‐like growth factor‐I axis, and insulin secretion in hyperandrogenic adolescents publication-title: Fertil Steril – volume: 66 start-page: 266 year: 1988 end-page: 72 article-title: Insulin regulates the serum levels of low molecular weight insulin‐like growth factor binding protein publication-title: J Clin Endocrinol Metab – volume: 80 start-page: 2966 year: 1995 end-page: 73 article-title: Metabolic features of polycystic ovary syndrome are found in adolescent girls with hyperandrogenism publication-title: J Clin Endocrinol Metab – volume: 82 start-page: 2283 year: 1997 end-page: 8 article-title: Hyperinsulinemia and decreased insulin‐like growth factor‐binding protein‐1 are common features in prepubertal and pubertal girls with a history of premature pubarche publication-title: J Clin Endocrinol Metab – volume: 81 start-page: 3892 year: 1996 end-page: 7 article-title: Insulin‐like growth factors enhanced steroidogenic enzyme and corticotopin receptor messenger ribonucleic acid levels and corticotropin steroidogenic responsivencess in cultured human adrenocortical cells publication-title: J Clin Endocrinol Metab – volume: 74 start-page: 254 year: 1992 end-page: 7 article-title: Natural history of premature pubarche: an auxological study publication-title: J Clin Endocrinol Metab – volume: 41 start-page: 7 issue: Suppl 2 year: 1994 end-page: 13 article-title: Normal and almost normal variations in pubertal development. Premature pubarche and premature thelarche revisited publication-title: Horm Res – volume: 83 start-page: 3558 year: 1998 end-page: 62 article-title: Precocious pubarche, hyperinsulinism and ovarian hyperandrogenism in girls: relation to reduced fetal growth publication-title: J Clin Endocrinol Metab – volume: 46 start-page: 320 year: 1999 end-page: 2 article-title: Precocious pubarche, dyslipidemia, and low IGF binding protein‐1 in girls: relation to reduced prenatal growth publication-title: Pediatr Res – volume: 118 start-page: 326 year: 1983 end-page: 37 article-title: Plasma insulin and lipoprotein concentrations: an atherogenic association publication-title: Am J Epidemiol – volume: 76 start-page: 1599 year: 1993 end-page: 1603 article-title: Postpubertal outcome in girls diagnosed of premature pubarche during childhood: increased frequency of functional ovarian hyuperandrogenism publication-title: J Clin Endocrinol Metab – volume: 16 start-page: 322 year: 1995 end-page: 53 article-title: Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion publication-title: Endocr Rev – volume: 81 start-page: 2854 year: 1996 end-page: 64 article-title: Insulin, somatotropic, and luteinizing hormone axes in lean and obese women with polycystic ovary syndrome: common and distinct features publication-title: J Clin Endocrinol Metab – volume: 148 start-page: 1339 year: 1993 end-page: 40 article-title: The insulin resistance‐dyslipidemia syndrome: the most prevalent cause of coronary artery disease publication-title: CMAJ – volume: 335 start-page: 617 year: 1996 end-page: 23 article-title: Decreases in ovarian cytochrome P450c17α activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome publication-title: N Engl J Med – volume: 81 start-page: 3299 year: 1996 end-page: 306 article-title: The insulin sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome publication-title: J Clin Endocrinol Metab – volume: 24 start-page: 435 year: 1997 end-page: 52 article-title: Cross‐sectional growth study of the child and adolescent population of Catalonia (Spain) publication-title: Ann Hum Biol – volume: 327 start-page: 157 year: 1992 end-page: 62 article-title: Detection of functional ovarian hyperandrogenism in women with androgen excess publication-title: N Engl J Med – volume: 76 start-page: 273 year: 1993 end-page: 4 article-title: Sex hormone‐binding globulin: a marker for hyperinsulinemia and/or insulin resistance? 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| SubjectTerms | Birth Weight Child Female Functional ovarian hyperandrogenism Humans hyperinsulinism Insulin Resistance - physiology Insulin-Like Growth Factor I - physiology low birth weight Ovary - physiopathology Polycystic Ovary Syndrome - physiopathology premature pubarche Puberty, Precocious - metabolism Puberty, Precocious - physiopathology |
| Title | Endocrinology and metabolism after premature pubarche in girls |
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