Acute respiratory distress caused by Neosartorya udagawae

• Published in: Medical mycology case reports Vol. 6; no. C; pp. 1 - 5
• Main Authors: Farrell, John J, Kasper, Douglas J, Taneja, Deepak, Baman, Sudhakar, O'Rourke, Lindsay M, Lowery, Kristin S, Sampath, Rangarajan, Bonomo, Robert A, Peterson, Stephen W
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier 01-10-2014
• Subjects: animal pathogenic fungi; ARDS; Aspergillosis; Aspergillus fumigatus; axenic culture; calmodulin; case studies; Diagnostic mycology; genes; internal transcribed spacers; Molecular microbiology; mycoses; Neosartorya; pathogen identification; patients; sequence analysis; tubulin; Diagnostic mycology; Molecular microbiology; ARDS; Aspergillosis
• ISSN: 2211-7539; 2211-7539
• DOI: 10.1016/j.mmcr.2014.07.003

We describe the first reported case of acute respiratory distress syndrome (ARDS) attributed to Neosartorya udagawae infection. This mold grew rapidly in cultures of multiple respiratory specimens from a previously healthy 43-year-oldwoman. Neosartorya spp. are a recently recognized cause of invasive disease in immunocompromised patients that can be mistaken for their sexual teleomorph, Aspergillus fumigatus. Because the cultures were sterile, phenotypic identification was not possible. DNA sequencing of ITS, calmodulin and β-tubulin genes supported identification of Neosartory audagawae. Our case is the first report of ARDS associated with Neosartorya sp. infection and defines a new clinical entity.