Nimodipine Ophthalmic Formulations for Management of Glaucoma

Purpose Preparation and evaluation of topical ophthalmic formulations containing nimodipine-CD complexes prepared using HP-β-CD, SBE-β-CD and M-β-CD for the management of glaucoma. Methods Nimodipine-CD complexes were prepared using a freeze-drying method. Two different molar ratios (NMD:CD) were us...

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Bibliographic Details
Published in:	Pharmaceutical research Vol. 34; no. 4; pp. 809 - 824
Main Authors:	Maria, Doaa Nabih, Abd-Elgawad, Abd-Elgawad Helmy, Soliman, Osama Abd-Elazeem, El-dahan, Marwa Salah, Jablonski, Monica M.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-04-2017 Springer Springer Nature B.V
Subjects:	2-Hydroxypropyl-beta-cyclodextrin - chemistry Administration, Ophthalmic Animals beta-Cyclodextrins - chemistry Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Brinzolamide Chemistry, Pharmaceutical Chitosan - chemistry Clinical outcomes Cyclodextrins Cytotoxicity Drug Liberation Freeze Drying Glaucoma Glaucoma - drug therapy Hypromellose Derivatives - chemistry Intraocular Pressure Medical Law Mice Mice, Inbred C57BL Nimodipine Nimodipine - chemistry Nimodipine - pharmacology Ophthalmic Solutions Pharmacology/Toxicology Pharmacy Prescription drugs Research Paper IOP nimodipine ophthalmic cytotoxicity cyclodextrin
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