Blockade of cardiac potassium and other channels by antihistamines

The use of terfenadine and astemizole, two long-acting nonsedating histamine H1 receptor antagonists, has been associated with prolongation of the QT interval, development of ventricular arrhythmias, particularly torsade de pointes, and sudden cardiac death. Both drugs block the rapidly activating c...

Full description

Saved in:

Bibliographic Details
Published in:	Drug safety Vol. 21; no. Supplement 1; pp. 11 - 18
Main Authors:	DELPON, E, VALENZUELA, C, TAMARGO, J
Format:	Conference Proceeding Journal Article
Language:	English
Published:	Auckland Adis international 1999
Subjects:	Animals Biological and medical sciences Drug toxicity and drugs side effects treatment Heart - drug effects Histamine Antagonists - pharmacology Humans Ion Channels - antagonists & inhibitors Medical sciences Myocardium - metabolism Pharmacology. Drug treatments Potassium Channel Blockers Toxicity: cardiovascular system Human Wave burst Arrhythmia Pathogenesis Toxicity Cardiovascular disease Ionic channel Ionic current Antihistaminic Excitability disorder Heart disease Antagonist H1 Histamine receptor Potassium
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!