Activation of the Neutrophil NADPH Oxidase Is Inhibited by SB 203580, a Specific Inhibitor of SAPK2/p38
Activation of the neutrophil NADPH oxidase by either the bacterial peptide fMLP or phorbol myristate acetate (PMA) is partially suppressed by SB 203580, a specific inhibitor of the MAP kinase family member, SAPK2/p38. The concentration of SB 203580 that suppresses activation of NADPH oxidase is simi...
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| Published in: | Biochemical and biophysical research communications Vol. 259; no. 2; pp. 465 - 470 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier Inc
07-06-1999
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| Abstract | Activation of the neutrophil NADPH oxidase by either the bacterial peptide fMLP or phorbol myristate acetate (PMA) is partially suppressed by SB 203580, a specific inhibitor of the MAP kinase family member, SAPK2/p38. The concentration of SB 203580 that suppresses activation of NADPH oxidase is similar to that which inhibits SAPK2/p38 in vitro, and both fMLP and PMA induce an extremely rapid and potent activation of SAPK2/p38 in neutrophils. SB 203580 does not exert its effect by preventing the neutrophil priming reaction, by suppressing the phosphorylation of p47phax, or by preventing the translocation of p47phax/p67phax to the plasma membrane. |
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| AbstractList | Activation of the neutrophil NADPH oxidase by either the bacterial peptide fMLP or phorbol myristate acetate (PMA) is partially suppressed by SB 203580, a specific inhibitor of the MAP kinase family member, SAPK2/p38. The concentration of SB 203580 that suppresses activation of NADPH oxidase is similar to that which inhibits SAPK2/p38 in vitro, and both fMLP and PMA induce an extremely rapid and potent activation of SAPK2/p38 in neutrophils. SB 203580 does not exert its effect by preventing the neutrophil priming reaction, by suppressing the phosphorylation of p47phax, or by preventing the translocation of p47phax/p67phax to the plasma membrane. |
| Author | Lal, Aroon S. Rouse, John Segal, Anthony W. Clifton, Andrew D. Cohen, Philip |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10362531$$D View this record in MEDLINE/PubMed |
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| Snippet | Activation of the neutrophil NADPH oxidase by either the bacterial peptide fMLP or phorbol myristate acetate (PMA) is partially suppressed by SB 203580, a... |
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| SubjectTerms | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Humans Imidazoles - pharmacology Mitogen-Activated Protein Kinases N-Formylmethionine Leucyl-Phenylalanine - pharmacology NADPH Oxidases - antagonists & inhibitors Neutrophils - enzymology p38 Mitogen-Activated Protein Kinases Phosphorylation Pyridines - pharmacology Superoxides - metabolism Tetradecanoylphorbol Acetate - pharmacology |
| Title | Activation of the Neutrophil NADPH Oxidase Is Inhibited by SB 203580, a Specific Inhibitor of SAPK2/p38 |
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