Inhibition of advanced glycation end products and protein oxidation by leaf extracts and phenolics from Chilean bean landraces
[Display omitted] •Leaf extracts from six Chilean landraces of Phaseolus vulgaris were investigated.•Some 26 compounds were identified from the most active sample by HPLC-MS/MS.•Pearson’s analysis shows strong correlations between phenolics and AGEs inhibition.•Caffeoyl malic acid and rutin synergis...
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| Published in: | Journal of functional foods Vol. 98; p. 105270 |
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| Main Authors: | , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier Ltd
01-11-2022
Elsevier |
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| Abstract | [Display omitted]
•Leaf extracts from six Chilean landraces of Phaseolus vulgaris were investigated.•Some 26 compounds were identified from the most active sample by HPLC-MS/MS.•Pearson’s analysis shows strong correlations between phenolics and AGEs inhibition.•Caffeoyl malic acid and rutin synergistically inhibit AGEs and protein oxidation.
Phenolics can decrease the levels of advanced glycation end products (AGEs) from proteins, but their mechanisms in complex mixtures are poorly understood. Leaf extracts and the main phenolics from Chilean bean (Phaseolus vulgaris) landraces were assessed for their capacity to inhibit AGEs and oxidative modifications on bovine serum albumin incubated with glucose. The leaf extracts of six bean landraces decreased AGEs (fluorescent AGEs and carboxymethyl lysine) and oxidative (Kyn, Di-Tyr, protein carbonyls) modifications. Fluorescent AGEs were characterized by time-resolved techniques. The composition of the extracts was determined by HPLC-DAD-Q-TOF-MS/MS, and the main compounds were quantified by HPLC. Correlations between the levels of AGEs or protein carbonyls with the main phenolics suggested synergic effects of caffeoyl malic acid (CMA) and rutin. The synergic effect was evaluated using mixtures of rutin and CMA, showing a strong decrease in fluorescent AGEs and protein carbonylation compared with the pure single compounds, supporting this finding. |
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| AbstractList | [Display omitted]
•Leaf extracts from six Chilean landraces of Phaseolus vulgaris were investigated.•Some 26 compounds were identified from the most active sample by HPLC-MS/MS.•Pearson’s analysis shows strong correlations between phenolics and AGEs inhibition.•Caffeoyl malic acid and rutin synergistically inhibit AGEs and protein oxidation.
Phenolics can decrease the levels of advanced glycation end products (AGEs) from proteins, but their mechanisms in complex mixtures are poorly understood. Leaf extracts and the main phenolics from Chilean bean (Phaseolus vulgaris) landraces were assessed for their capacity to inhibit AGEs and oxidative modifications on bovine serum albumin incubated with glucose. The leaf extracts of six bean landraces decreased AGEs (fluorescent AGEs and carboxymethyl lysine) and oxidative (Kyn, Di-Tyr, protein carbonyls) modifications. Fluorescent AGEs were characterized by time-resolved techniques. The composition of the extracts was determined by HPLC-DAD-Q-TOF-MS/MS, and the main compounds were quantified by HPLC. Correlations between the levels of AGEs or protein carbonyls with the main phenolics suggested synergic effects of caffeoyl malic acid (CMA) and rutin. The synergic effect was evaluated using mixtures of rutin and CMA, showing a strong decrease in fluorescent AGEs and protein carbonylation compared with the pure single compounds, supporting this finding. Phenolics can decrease the levels of advanced glycation end products (AGEs) from proteins, but their mechanisms in complex mixtures are poorly understood. Leaf extracts and the main phenolics from Chilean bean (Phaseolus vulgaris) landraces were assessed for their capacity to inhibit AGEs and oxidative modifications on bovine serum albumin incubated with glucose. The leaf extracts of six bean landraces decreased AGEs (fluorescent AGEs and carboxymethyl lysine) and oxidative (Kyn, Di-Tyr, protein carbonyls) modifications. Fluorescent AGEs were characterized by time-resolved techniques. The composition of the extracts was determined by HPLC-DAD-Q-TOF-MS/MS, and the main compounds were quantified by HPLC. Correlations between the levels of AGEs or protein carbonyls with the main phenolics suggested synergic effects of caffeoyl malic acid (CMA) and rutin. The synergic effect was evaluated using mixtures of rutin and CMA, showing a strong decrease in fluorescent AGEs and protein carbonylation compared with the pure single compounds, supporting this finding. |
| ArticleNumber | 105270 |
| Author | Márquez, Katherine Nina, Nélida Paillan, Hernán Fuentealba, Denis Vejar-Vivar, Carmina Alarcon-Espósito, Jazmin Cruz, Nadia Theoduloz, Cristina Schmeda-Hirschmann, Guillermo Burgos-Edwards, Alberto Ávila, Felipe |
| Author_xml | – sequence: 1 givenname: Felipe surname: Ávila fullname: Ávila, Felipe email: favilac@utalca.cl organization: Escuela de Nutrición y Dietética, Facultad de Ciencias de la Salud, Universidad de Talca, Campus Lircay, 3480094 Talca, Chile – sequence: 2 givenname: Nadia surname: Cruz fullname: Cruz, Nadia organization: Escuela de Nutrición y Dietética, Facultad de Ciencias de la Salud, Universidad de Talca, Campus Lircay, 3480094 Talca, Chile – sequence: 3 givenname: Jazmin surname: Alarcon-Espósito fullname: Alarcon-Espósito, Jazmin organization: Centro de Estudios en Alimentos Procesados CEAP, Campus Lircay, Talca 3480094, Talca, Chile – sequence: 4 givenname: Nélida surname: Nina fullname: Nina, Nélida organization: Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Campus Lircay, 3480094 Talca, Chile – sequence: 5 givenname: Hernán surname: Paillan fullname: Paillan, Hernán organization: Facultad de Ciencias Agrarias, Universidad de Talca, Campus Lircay, 3480094 Talca, Chile – sequence: 6 givenname: Katherine surname: Márquez fullname: Márquez, Katherine organization: Centro de Estudios en Alimentos Procesados CEAP, Campus Lircay, Talca 3480094, Talca, Chile – sequence: 7 givenname: Denis surname: Fuentealba fullname: Fuentealba, Denis organization: Laboratorio de Química Supramolecular y Fotobiología, Departamento de Química Física, Escuela de Química, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Macul, Santiago 7820436, Chile – sequence: 8 givenname: Alberto surname: Burgos-Edwards fullname: Burgos-Edwards, Alberto organization: Centro de Estudios en Alimentos Procesados CEAP, Campus Lircay, Talca 3480094, Talca, Chile – sequence: 9 givenname: Cristina surname: Theoduloz fullname: Theoduloz, Cristina organization: Centro de Estudios en Alimentos Procesados CEAP, Campus Lircay, Talca 3480094, Talca, Chile – sequence: 10 givenname: Carmina surname: Vejar-Vivar fullname: Vejar-Vivar, Carmina organization: Departamento de Análisis Instrumental, Facultad de Farmacia, Universidad de Concepción, PO Box 160-C, Concepción 4081447, Chile – sequence: 11 givenname: Guillermo surname: Schmeda-Hirschmann fullname: Schmeda-Hirschmann, Guillermo organization: Centro de Estudios en Alimentos Procesados CEAP, Campus Lircay, Talca 3480094, Talca, Chile |
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| Keywords | PBS BCA Kyn CML Di-Tyr Synergic effects AG AGEs Rutin EDTA Protein glycation Caffeoyl malic acid NCD BSA SDS-PAGE Phaseolus vulgaris LDL ANOVA CMA Protein crosslinking |
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•Leaf extracts from six Chilean landraces of Phaseolus vulgaris were investigated.•Some 26 compounds were identified from the most active... Phenolics can decrease the levels of advanced glycation end products (AGEs) from proteins, but their mechanisms in complex mixtures are poorly understood. Leaf... |
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| SubjectTerms | Caffeoyl malic acid Phaseolus vulgaris Protein crosslinking Protein glycation Rutin Synergic effects |
| Title | Inhibition of advanced glycation end products and protein oxidation by leaf extracts and phenolics from Chilean bean landraces |
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