Coordination of metabolism, arousal, and reward by orexin/hypocretin neurons

Orexin/hypocretin neurons located in the lateral hypothalamus play a critical role in the maintenance of arousal and contribute to the regulation of multiple homeostatic and behavioral processes. In this issue of the JCI, Tan and Hang et al. report that feeding a high-fat diet to mice compromised th...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 130; no. 9; pp. 4540 - 4542
Main Authors:	Michael, Natalie J, Elmquist, Joel K
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01-09-2020
Subjects:	Animals Arousal Intracellular Signaling Peptides and Proteins - genetics Male Mice Mice, Obese Neural circuitry Neurons Neuropeptides - genetics Neurophysiology Obesity Orexins Physiological aspects Reward
Online Access:	Get full text
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Summary:	Orexin/hypocretin neurons located in the lateral hypothalamus play a critical role in the maintenance of arousal and contribute to the regulation of multiple homeostatic and behavioral processes. In this issue of the JCI, Tan and Hang et al. report that feeding a high-fat diet to mice compromised the function of the orexin system, leading to impairments in reward-seeking and active coping mechanisms. The researchers observed changes at the cellular and circuit levels suggesting that reduced excitability of orexin neurons affects behavior through induction of a hypoarousal state.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Commentary-1
ISSN:	0021-9738 1558-8238
DOI:	10.1172/JCI140585