Role of Mesenchymal Stromal Cells as Therapeutic Agents: Potential Mechanisms of Action and Implications in Their Clinical Use

Due to the great therapeutic interest that involves the translation of mesenchymal stromal cells (MSCs) into clinical practice, they have been widely studied as innovative drugs, in order to treat multiple pathologies. MSC-based cell therapy involves the administration of MSCs either locally or syst...

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Published in:	Journal of clinical medicine Vol. 9; no. 2; p. 445
Main Authors:	Jimenez-Puerta, Gonzalo José, Marchal, Juan Antonio, López-Ruiz, Elena, Gálvez-Martín, Patricia
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 06-02-2020 MDPI
Subjects:	Adapter proteins Adipocytes Antigens Blood vessels Body fat Bone marrow Cell adhesion & migration Chemokines Clinical medicine Endothelium Fibroblasts Growth factors Immune system Kinases Ligands Review Tumor necrosis factor-TNF Umbilical cord mechanism of action immunomodulation homing mesenchymal stromal cells
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Abstract	Due to the great therapeutic interest that involves the translation of mesenchymal stromal cells (MSCs) into clinical practice, they have been widely studied as innovative drugs, in order to treat multiple pathologies. MSC-based cell therapy involves the administration of MSCs either locally or systemically into the receptor body where they can traffic and migrate towards the affected tissue and participate in the process of healing. The therapeutic effects of MSCs compromise of different mechanisms such as the functional integration of differentiated MSCs into diseased host tissue after transplantation, their paracrine support, and their impact on the regulation of both the innate and the acquired immune system. Here, we establish and provide recent advances about the principal mechanisms of action through which MSCs can perform their activity and effect as a therapeutic tool. The purpose of this review is to examine and discuss the MSCs capacity of migration, their paracrine effect, as well as MSC-mediated modifications on immune cell responses.
AbstractList	Due to the great therapeutic interest that involves the translation of mesenchymal stromal cells (MSCs) into clinical practice, they have been widely studied as innovative drugs, in order to treat multiple pathologies. MSC-based cell therapy involves the administration of MSCs either locally or systemically into the receptor body where they can traffic and migrate towards the affected tissue and participate in the process of healing. The therapeutic effects of MSCs compromise of different mechanisms such as the functional integration of differentiated MSCs into diseased host tissue after transplantation, their paracrine support, and their impact on the regulation of both the innate and the acquired immune system. Here, we establish and provide recent advances about the principal mechanisms of action through which MSCs can perform their activity and effect as a therapeutic tool. The purpose of this review is to examine and discuss the MSCs capacity of migration, their paracrine effect, as well as MSC-mediated modifications on immune cell responses.
Author	Marchal, Juan Antonio Jimenez-Puerta, Gonzalo José López-Ruiz, Elena Gálvez-Martín, Patricia
AuthorAffiliation	6 Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, 18016 Granada, Spain 5 Department of Health Sciences, University of Jaén, 23071 Jaén, Spain 7 R&D Human Health, Bioibérica S.A.U., 08029 Barcelona, Spain 4 Excellence Research Unit “Modeling Nature” (MNat), University of Granada, 18016 Granada, Spain 1 Biosanitary Research Institute of Granada (ibs.GRANADA), University Hospitals of Granada-University of Granada, 18016 Granada, Spain; gonzalojimenez@telefonica.net (G.J.J.-P.); jmarchal@go.ugr.es (J.A.M.) 3 Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, 18016 Granada, Spain 2 Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research (CIBM), University of Granada, 18016 Granada, Spain
AuthorAffiliation_xml	– name: 6 Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, 18016 Granada, Spain – name: 5 Department of Health Sciences, University of Jaén, 23071 Jaén, Spain – name: 7 R&D Human Health, Bioibérica S.A.U., 08029 Barcelona, Spain – name: 2 Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research (CIBM), University of Granada, 18016 Granada, Spain – name: 4 Excellence Research Unit “Modeling Nature” (MNat), University of Granada, 18016 Granada, Spain – name: 1 Biosanitary Research Institute of Granada (ibs.GRANADA), University Hospitals of Granada-University of Granada, 18016 Granada, Spain; gonzalojimenez@telefonica.net (G.J.J.-P.); jmarchal@go.ugr.es (J.A.M.) – name: 3 Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, 18016 Granada, Spain
Author_xml	– sequence: 1 givenname: Gonzalo José surname: Jimenez-Puerta fullname: Jimenez-Puerta, Gonzalo José organization: Biosanitary Research Institute of Granada (ibs.GRANADA), University Hospitals of Granada-University of Granada, 18016 Granada, Spain – sequence: 2 givenname: Juan Antonio orcidid: 0000-0002-4996-8261 surname: Marchal fullname: Marchal, Juan Antonio organization: Excellence Research Unit "Modeling Nature" (MNat), University of Granada, 18016 Granada, Spain – sequence: 3 givenname: Elena surname: López-Ruiz fullname: López-Ruiz, Elena organization: Department of Health Sciences, University of Jaén, 23071 Jaén, Spain – sequence: 4 givenname: Patricia orcidid: 0000-0001-9724-8560 surname: Gálvez-Martín fullname: Gálvez-Martín, Patricia organization: R&D Human Health, Bioibérica S.A.U., 08029 Barcelona, Spain
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Copyright	2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2020 by the authors. 2020
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Snippet	Due to the great therapeutic interest that involves the translation of mesenchymal stromal cells (MSCs) into clinical practice, they have been widely studied...
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SubjectTerms	Adapter proteins Adipocytes Antigens Blood vessels Body fat Bone marrow Cell adhesion & migration Chemokines Clinical medicine Endothelium Fibroblasts Growth factors Immune system Kinases Ligands Review Tumor necrosis factor-TNF Umbilical cord
Title	Role of Mesenchymal Stromal Cells as Therapeutic Agents: Potential Mechanisms of Action and Implications in Their Clinical Use
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