New dibenzocyclooctadiene lignans from Kadsura induta with their anti-inflammatory activity

• Published in: RSC advances Vol. 12; no. 39; pp. 25433 - 25439
• Main Authors: Tai, Bui Huu, Yen, Pham Hai, Hoang, Nguyen Huy, Thanh Huong, Phan Thi, Dung, Nguyen Viet, Van Thanh, Bui, Cuong, Nguyen The, Bang, Ngo Anh, Nhiem, Nguyen Xuan, Van Kiem, Phan
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 05-09-2022; The Royal Society of Chemistry
• Subjects: Binding; Chemistry; Lignans; Molecular docking; NMR; Nuclear magnetic resonance; Proteins
• ISSN: 2046-2069; 2046-2069
• DOI: 10.1039/d2ra05052h

Five new dibenzocyclooctadiene lignans, named kadsuindutains A-E (1-5), and three known ones schizanrin F (6), schizanrin O (7), and schisantherin J (8) were isolated from the stems of
. Their structures were determined by analyses of HR-ESI-MS, NMR, and ECD spectra. Compounds 1-5 contain a 2',4'-dioxygenated-2',3'-dimethylbutyryl moiety which is rarely reported for dibenzocyclooctadiene lignans. Molecular docking predicted that compounds 1-8 displayed good binding affinity to the active site of iNOS and TNF-α proteins but unstable binding to the active site of COX-2 protein. Additionally,
experiments showed that compounds 1-8 inhibited NO production in LPS-activated RAW264.7 cells with IC
values from 10.7 μM to 34.0 μM, compared to the positive control L-NMMA (IC
= 31.2 μM).