Alcohol-induced rosacea flushing blocked by naloxone

We evaluated the roles of endogenous opioid peptides and histamine in the pathophysiology of alcohol-induced facial flushing in rosacea. Non-diabetic patients with rosacea ingested 360 ml of 6% ethanol after receiving either subcutaneous naloxone hydrochloride or oral chloropheniramine maleate. Only...

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Bibliographic Details
Published in:	British journal of dermatology (1951) Vol. 107; no. 1; p. 59
Main Authors:	Bernstein, J E, Soltani, K
Format:	Journal Article
Language:	English
Published:	England 01-07-1982
Subjects:	Adult Alcoholic Beverages - adverse effects Chlorpheniramine - pharmacology Double-Blind Method Face Female Humans Male Middle Aged Naloxone - pharmacology Rosacea - physiopathology Skin - blood supply Skin Temperature - drug effects Vasodilation - drug effects
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Summary:	We evaluated the roles of endogenous opioid peptides and histamine in the pathophysiology of alcohol-induced facial flushing in rosacea. Non-diabetic patients with rosacea ingested 360 ml of 6% ethanol after receiving either subcutaneous naloxone hydrochloride or oral chloropheniramine maleate. Only pretreatment with naloxone blocked the alcohol-induced rosacea flushing (AIRF), suggesting an active role of endogenous enkephalin and/or endorphin in this vascular reactivity. In this respect, AIRF is similar to chlorpropamide alcohol flushing and menopausal flushing.
ISSN:	0007-0963
DOI:	10.1111/j.1365-2133.1982.tb00290.x