Surgical outcomes of patients after treatment of ruptured anterior communicating artery aneurysms: “real-world” evidence from southern Thailand

• Published in: Chinese neurosurgical journal Vol. 7; no. 1; pp. 1 - 42
• Main Authors: Sungkaro, Kanisorn, Tunthanathip, Thara, Taweesomboonyat, Chin, Kaewborisutsakul, Anukoon
• Format: Journal Article
• Language: English
• Published: London BioMed Central 02-10-2021; BMC
• Subjects: Aneurysm clipping; Aneurysms; Anterior cerebral artery; Glasgow Coma Scale; Hemorrhage; Hospitals; Hypertension; Low- to middle-income countries; Medical imaging; Medical records; Mortality; Neurosurgery; Patients; Subarachnoid hemorrhage; Surgery; Surgical outcomes; Veins & arteries; Thailand
• ISSN: 2057-4967; 2095-9370; 2057-4967
• DOI: 10.1186/s41016-021-00259-9

Background Anterior communicating artery (AComA) aneurysm rupture is the most common cause of subarachnoid hemorrhage worldwide. In this study, we aimed to determine the factors associated with a poor clinical outcome in patients with ruptured AComA aneurysms undergoing microsurgical clipping. Methods We retrospectively reviewed the clinical and radiologic features as well as clinical outcomes of 150 consecutive patients with ruptured AComA aneurysm who underwent surgical clipping during the 11-year study period. Logistic regression analysis was performed to identify independent factors associated with unfavorable clinical outcomes (defined as a modified Rankin scale score of 3–6). Results The study included 83 male and 67 female patients, with a mean age of 51.3 ± 11.5 years. At admission, most of the patients had good neurological status, including 97 (64.7%) patients with a Hunt and Hess grade of 1 or 2 and 109 (72.6%) patients with a World Federation of Neurosurgical Societies grade of 1 or 2. Unfavorable outcomes at 6 months were observed in 23 (22.0%) patients, and the 6-month mortality rate was 8.0%. Multivariate analysis showed that preoperative intraventricular hemorrhage (odds ratio [OR], 19.66; 95% confidence interval [CI], 5.10–75.80; P < 0.001), A1 hypoplasia (OR, 8.90; 95% CI, 2.82–28.04; P < 0.001), and postoperative cerebral infarction (OR, 3.21; 95% CI, 1.16–8.88; P = 0.025) were strong independent risk factors for unfavorable outcomes. Conclusions Proper management of preoperative intraventricular hemorrhage, A1 hypoplasia, and intensive care for postoperative brain infarction are warranted for improved surgical outcomes in patients with ruptured AComA aneurysm undergoing surgical clipping.