Detection of intracellular bacterial communities in a child with Escherichia coli recurrent urinary tract infections
Abstract The formation of intracellular bacterial communities (IBC) has been proposed as a new pathogenic model for urinary tract infections. Scarce reports describe this phenomenon in humans. We describe the presence of IBC in uroepithelial cells of a child with recurrent urinary infections. Urine...
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| Published in: | Pathogens and disease Vol. 68; no. 3; pp. 78 - 81 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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Oxford, UK
Blackwell Publishing Ltd
01-08-2013
Oxford University Press |
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| Abstract | Abstract
The formation of intracellular bacterial communities (IBC) has been proposed as a new pathogenic model for urinary tract infections. Scarce reports describe this phenomenon in humans. We describe the presence of IBC in uroepithelial cells of a child with recurrent urinary infections. Urine specimen was collected from a child with
Escherichia coli
UTI and analyzed by light and confocal laser scanning microscopy (CLSM). The capability of this strain to produce intracellular infection in bladder tissue was confirmed in mice models.
Escherichia coli
phylogenetic group, presence of virulence factors genes, and its multiple locus sequence type were determined. CLSM showed large collections of morphologically coccoid and rod bacteria in eukaryotic cells cytoplasm, even seemingly protruding from the cells.
Escherichia coli
EC7U, ST3626, harbored type 1, P, and S/F1C fimbriae and K1 capsule genes. In this report, we confirm the presence of IBC in children with UTI, as it has been described before in women.
This work verifies that
E. coli
can be intracellular in cases of severe recurrent urinary tract infections. |
|---|---|
| AbstractList | The formation of intracellular bacterial communities (IBC) has been proposed as a new pathogenic model for urinary tract infections. Scarce reports describe this phenomenon in humans. We describe the presence of IBC in uroepithelial cells of a child with recurrent urinary infections. Urine specimen was collected from a child with Escherichia coli UTI and analyzed by light and confocal laser scanning microscopy (CLSM). The capability of this strain to produce intracellular infection in bladder tissue was confirmed in mice models. Escherichia coli phylogenetic group, presence of virulence factors genes, and its multiple locus sequence type were determined. CLSM showed large collections of morphologically coccoid and rod bacteria in eukaryotic cells cytoplasm, even seemingly protruding from the cells. Escherichia coli EC7U, ST3626, harbored type 1, P, and S/F1C fimbriae and K1 capsule genes. In this report, we confirm the presence of IBC in children with UTI, as it has been described before in women.
This work verifies that E. coli can be intracellular in cases of severe recurrent urinary tract infections. Abstract The formation of intracellular bacterial communities (IBC) has been proposed as a new pathogenic model for urinary tract infections. Scarce reports describe this phenomenon in humans. We describe the presence of IBC in uroepithelial cells of a child with recurrent urinary infections. Urine specimen was collected from a child with Escherichia coli UTI and analyzed by light and confocal laser scanning microscopy (CLSM). The capability of this strain to produce intracellular infection in bladder tissue was confirmed in mice models. Escherichia coli phylogenetic group, presence of virulence factors genes, and its multiple locus sequence type were determined. CLSM showed large collections of morphologically coccoid and rod bacteria in eukaryotic cells cytoplasm, even seemingly protruding from the cells. Escherichia coli EC7U, ST3626, harbored type 1, P, and S/F1C fimbriae and K1 capsule genes. In this report, we confirm the presence of IBC in children with UTI, as it has been described before in women. This work verifies that E. coli can be intracellular in cases of severe recurrent urinary tract infections. The formation of intracellular bacterial communities (IBC) has been proposed as a new pathogenic model for urinary tract infections. Scarce reports describe this phenomenon in humans. We describe the presence of IBC in uroepithelial cells of a child with recurrent urinary infections. Urine specimen was collected from a child with Escherichia coli UTI and analyzed by light and confocal laser scanning microscopy (CLSM). The capability of this strain to produce intracellular infection in bladder tissue was confirmed in mice models. Escherichia coli phylogenetic group, presence of virulence factors genes, and its multiple locus sequence type were determined. CLSM showed large collections of morphologically coccoid and rod bacteria in eukaryotic cells cytoplasm, even seemingly protruding from the cells. Escherichia coli EC7U, ST3626, harbored type 1, P, and S/F1C fimbriae and K1 capsule genes. In this report, we confirm the presence of IBC in children with UTI, as it has been described before in women. |
| Author | Araujo, Lucia Scavone, Paola Zunino, Pablo Robino, Luciana Algorta, Gabriela Vignoli, Rafael |
| Author_xml | – sequence: 1 givenname: Luciana surname: Robino fullname: Robino, Luciana organization: Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay – sequence: 2 givenname: Paola surname: Scavone fullname: Scavone, Paola organization: Departamento de Microbiología, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay – sequence: 3 givenname: Lucia surname: Araujo fullname: Araujo, Lucia organization: Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay – sequence: 4 givenname: Gabriela surname: Algorta fullname: Algorta, Gabriela organization: Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay – sequence: 5 givenname: Pablo surname: Zunino fullname: Zunino, Pablo organization: Departamento de Microbiología, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay – sequence: 6 givenname: Rafael surname: Vignoli fullname: Vignoli, Rafael email: rvignoli@higiene.edu.uy organization: Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23733378$$D View this record in MEDLINE/PubMed |
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| Copyright | 2013 Federation of European Microbiological Societies. 2013 2013 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved 2013 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved. 2013 Federation of European Microbiological Societies. |
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| Keywords | UTI children intracellular bacterial communities UPEC Escherichia coli |
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The formation of intracellular bacterial communities (IBC) has been proposed as a new pathogenic model for urinary tract infections. Scarce reports... The formation of intracellular bacterial communities (IBC) has been proposed as a new pathogenic model for urinary tract infections. Scarce reports describe... |
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| SubjectTerms | Animal models Animals Bacteria Bladder Child children Communities Confocal microscopy Cytoplasm Cytoplasm - microbiology Disease Models, Animal E coli Epithelial Cells - microbiology Escherichia coli Escherichia coli - classification Escherichia coli - genetics Escherichia coli - isolation & purification Escherichia coli Infections - microbiology Female Genes Genotype Humans Intracellular intracellular bacterial communities Mice Microscopy Multilocus Sequence Typing Phylogeny Pili Recurrence Scanning microscopy UPEC Urinary tract Urinary tract diseases Urinary tract infections Urinary Tract Infections - microbiology Urine Urine - cytology Urine - microbiology Urogenital system UTI Virulence Virulence factors Virulence Factors - genetics |
| Title | Detection of intracellular bacterial communities in a child with Escherichia coli recurrent urinary tract infections |
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