Topical nicotinamide modulates cellular energy metabolism and provides broad-spectrum protection against ultraviolet radiation-induced immunosuppression in humans

Summary Background Ultraviolet (UV) radiation can profoundly suppress the cutaneous immune system, thus enhancing carcinogenesis. Agents that prevent UV‐induced immunosuppression may thus reduce skin cancer. Nicotinamide (vitamin B3) prevents UV‐induced immunosuppression and carcinogenesis in mice,...

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Bibliographic Details
Published in:	British journal of dermatology (1951) Vol. 161; no. 6; pp. 1357 - 1364
Main Authors:	Sivapirabu, G., Yiasemides, E., Halliday, G.M., Park, J., Damian, D.L
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-12-2009
Subjects:	Administration, Topical Adult Aged Animals Apoptosis - drug effects Cells, Cultured delayed type hypersensitivity Dose-Response Relationship, Drug Energy Metabolism - drug effects Female Gene Expression - drug effects Humans Immunosuppression Male Mice Middle Aged niacin Niacinamide - administration & dosage Niacinamide - pharmacology photoprotection Reverse Transcriptase Polymerase Chain Reaction Skin - drug effects Skin - radiation effects skin cancer Skin Neoplasms - prevention & control Sunscreening Agents - administration & dosage Sunscreening Agents - pharmacology Ultraviolet Rays - adverse effects vitamin B3 Young Adult
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