Thermal degradation products derived from the smoke of Salvia divinorum leaves

• Published in: Tetrahedron letters Vol. 51; no. 41; pp. 5480 - 5482
• Main Authors: Ma, Zhongze, Deng, Gang, Dai, Ronghua, Xu, Wei, Liu-Chen, Lee-Yuan, Lee, David Y.W.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 13-10-2010
• Subjects: Affinity; Binding; Derivatives; Kappa opioid receptor; Receptors; Salvia divinorum; Salvinorin A; Smoke; Spectroscopy; Tetrahedrons; Thermal degradation; Smoke; Salvia divinorum; Salvinorin A; Kappa opioid receptor
• ISSN: 0040-4039; 1873-3581
• DOI: 10.1016/j.tetlet.2010.08.033

Smoking of
Salvia divinorum leaves is the most common method for its psychotropic effects. Eleven thermal degradation products, including a new neoclerodane diterpene derivative, were isolated from the smoke of
S. divinorum leaves, and their structures were identified by spectroscopic methods. The isolated compounds were evaluated for their binding affinities at the opioid receptors, and salvinorin A is still the most potent kappa opioid receptor agonist.